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Copper-Promoted C-Se Cross-Coupling of 2-Selenohydantoins with Arylboronic Acids in an Open Flask.
- Source :
-
ACS combinatorial science [ACS Comb Sci] 2019 Jun 10; Vol. 21 (6), pp. 456-464. Date of Electronic Publication: 2019 May 09. - Publication Year :
- 2019
-
Abstract
- The modification of Chan-Lam-Evans cross-coupling reaction for the selective Se-arylation of 2-selenohydantoins under base-free mild conditions via aryl boronic acids is described herein. This approach was used to synthesize novel 5-arylidene-3-substituted-2-(arylselanyl)-imidazoline-4-ones with high yields. The anticancer activity of the final compounds was evaluated in vitro against different cancer cells, and thus, the possibility of 5-arylidene-3-substituted-2-(arylselanyl)-imidazoline-4-ones successful application as cytotoxic agents was demonstrated.
- Subjects :
- Antineoplastic Agents chemical synthesis
Antineoplastic Agents pharmacology
Cell Line, Tumor
Cell Survival drug effects
Humans
Imidazolines chemical synthesis
Imidazolines pharmacology
Antineoplastic Agents chemistry
Boronic Acids chemistry
Copper chemistry
Hydantoins chemistry
Imidazolines chemistry
Selenium Compounds chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 2156-8944
- Volume :
- 21
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- ACS combinatorial science
- Publication Type :
- Academic Journal
- Accession number :
- 31009196
- Full Text :
- https://doi.org/10.1021/acscombsci.9b00021