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Specific class of intrapartum antibiotics relates to maturation of the infant gut microbiota: a prospective cohort study.
- Source :
-
BJOG : an international journal of obstetrics and gynaecology [BJOG] 2020 Jan; Vol. 127 (2), pp. 217-227. Date of Electronic Publication: 2019 Jun 05. - Publication Year :
- 2020
-
Abstract
- Objective: To evaluate the potential impact of intrapartum antibiotics, and their specific classes, on the infant gut microbiota in the first year of life.<br />Design: Prospective study of infants in the New Hampshire Birth Cohort Study (NHBCS).<br />Settings: Rural New Hampshire, USA.<br />Population or Sample: Two hundred and sixty-six full-term infants from the NHBCS.<br />Methods: Intrapartum antibiotic use during labour and delivery was abstracted from medical records. Faecal samples collected at 6 weeks and 1 year of age were characterised by 16S rRNA sequencing, and metagenomics analysis in a subset of samples.<br />Exposures: Maternal exposure to antibiotics during labour and delivery.<br />Main Outcome Measure: Taxonomic and functional profiles of faecal samples.<br />Results: Infant exposure to intrapartum antibiotics, particularly to two or more antibiotic classes, was independently associated with lower microbial diversity scores as well as a unique bacterial community at 6 weeks (GUnifrac, P = 0.02). At 1 year, infants in the penicillin-only group had significantly lower α diversity scores than infants not exposed to intrapartum antibiotics. Within the first year of life, intrapartum exposure to penicillins was related to a significantly lower increase in several taxa including Bacteroides, use of cephalosporins was associated with a significantly lower rise over time in Bifidobacterium and infants in the multi-class group experienced a significantly higher increase in Veillonella dispar.<br />Conclusions: Our findings suggest that intrapartum antibiotics alter the developmental trajectory of the infant gut microbiome, and specific antibiotic types may impact community composition, diversity and keystone immune training taxa.<br />Tweetable Abstract: Class of intrapartum antibiotics administered during delivery relates to maturation of infant gut microbiota.<br /> (© 2019 Royal College of Obstetricians and Gynaecologists.)
- Subjects :
- Bacteroides growth & development
Bacteroidetes
Bifidobacterium
Female
Humans
Infant, Newborn
Lactobacillus
Maternal Exposure
Mothers
Pregnancy
Prospective Studies
RNA, Ribosomal, 16S
Sequence Analysis, RNA
Term Birth
beta-Lactamases
Antibiotic Prophylaxis
Feces microbiology
Gastrointestinal Microbiome drug effects
Vagina microbiology
Subjects
Details
- Language :
- English
- ISSN :
- 1471-0528
- Volume :
- 127
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- BJOG : an international journal of obstetrics and gynaecology
- Publication Type :
- Academic Journal
- Accession number :
- 31006170
- Full Text :
- https://doi.org/10.1111/1471-0528.15799