Back to Search
Start Over
New potentials for 3-hydroxy-3-methyl-glutaryl-coenzymeA reductase inhibitors: Possible applications in retarding diabetic complications.
- Source :
-
Journal of cellular physiology [J Cell Physiol] 2019 Nov; Vol. 234 (11), pp. 19393-19405. Date of Electronic Publication: 2019 Apr 19. - Publication Year :
- 2019
-
Abstract
- The prevalence of diabetes mellitus is increasing all over the world and it is apparent that treatment of diabetic complications has the same importance as primary diabetes treatment and glycemic control. Diabetic complications occur as a result of prolonged hyperglycemia and its consequences, such as advanced glycation end products and reactive oxygen species. Impairment of lipid profile is also contributed to worsening diabetic complications. Therefore, it seems that the application of lipid-lowering agents may have positive effects on reversing diabetic complications besides glycemic control. Statins, a group of lipid-lowering compounds, have been shown to exert antioxidant, immunomodulatory, anti-inflammatory, and antiproliferative properties beyond their lipid-lowering effects. Furthermore, they have been reported to improve diabetic complications with different pathways. In this review, we will discuss the clinical importance, molecular biology of the most important microvascular/macrovascular diabetic complications, possible application of statins and their mechanism of action in retarding these complications.<br /> (© 2019 Wiley Periodicals, Inc.)
- Subjects :
- Diabetes Complications metabolism
Diabetes Complications pathology
Glycation End Products, Advanced metabolism
Humans
Hydroxymethylglutaryl CoA Reductases metabolism
Hyperglycemia metabolism
Hyperglycemia pathology
Lipid Metabolism drug effects
Lipids genetics
Reactive Oxygen Species metabolism
Diabetes Complications drug therapy
Hydroxymethylglutaryl CoA Reductases genetics
Hydroxymethylglutaryl-CoA Reductase Inhibitors therapeutic use
Hyperglycemia drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1097-4652
- Volume :
- 234
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Journal of cellular physiology
- Publication Type :
- Academic Journal
- Accession number :
- 31004363
- Full Text :
- https://doi.org/10.1002/jcp.28682