Back to Search
Start Over
Management of Central Nervous System Infections, Vientiane, Laos, 2003-2011.
- Source :
-
Emerging infectious diseases [Emerg Infect Dis] 2019 May; Vol. 25 (5), pp. 898-910. - Publication Year :
- 2019
-
Abstract
- During 2003-2011, we recruited 1,065 patients of all ages admitted to Mahosot Hospital (Vientiane, Laos) with suspected central nervous system (CNS) infection. Etiologies were laboratory confirmed for 42.3% of patients, who mostly had infections with emerging pathogens: viruses in 16.2% (mainly Japanese encephalitis virus [8.8%]); bacteria in 16.4% (including Orientia tsutsugamushi [2.9%], Leptospira spp. [2.3%], and Rickettsia spp. [2.3%]); and Cryptococcus spp. fungi in 6.6%. We observed no significant differences in distribution of clinical encephalitis and meningitis by bacterial or viral etiology. However, patients with bacterial CNS infection were more likely to have a history of diabetes than others. Death (26.3%) was associated with low Glasgow Coma Scale score, and the mortality rate was higher for patients with bacterial than viral infections. No clinical or laboratory variables could guide antibiotic selection. We conclude that high-dependency units and first-line treatment with ceftriaxone and doxycycline for suspected CNS infections could improve patient survival in Laos.
- Subjects :
- Adolescent
Adult
Central Nervous System Infections diagnosis
Central Nervous System Infections drug therapy
Child
Child, Preschool
Cross Infection drug therapy
Cross Infection etiology
Female
Health Policy
Humans
Infant
Infectious Encephalitis etiology
Infectious Encephalitis microbiology
Infectious Encephalitis virology
Laos
Male
Meningitis etiology
Meningitis microbiology
Meningitis virology
Prospective Studies
Young Adult
Central Nervous System Infections etiology
Subjects
Details
- Language :
- English
- ISSN :
- 1080-6059
- Volume :
- 25
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Emerging infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 31002063
- Full Text :
- https://doi.org/10.3201/eid2505.180914