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NDV-3A vaccination prevents C. albicans colonization of jugular vein catheters in mice.
- Source :
-
Scientific reports [Sci Rep] 2019 Apr 17; Vol. 9 (1), pp. 6194. Date of Electronic Publication: 2019 Apr 17. - Publication Year :
- 2019
-
Abstract
- NDV-3A, a novel fungal vaccine undergoing clinical trials, contains a recombinant version of the Candida albicans rAls3 N-terminus protein (rAls3p-N) in aluminum hydroxide. In a Phase 1b/2a clinical trial, NDV-3A protected women from recurrent vulvovaginal candidiasis. Here, we reveal that active immunization in mice with NDV-3A induces high titers of anti-rAls3p-N antibodies that interfere with C. albicans ability to adhere to and invade endothelial cells, and form biofilm in vitro. Anti-rAls3p-N antibodies also significantly inhibit yeast dispersal from the hyphal layers of biofilms. Compared to placebo, NDV-3A vaccination inhibited C. albicans dissemination to kidneys and prevented colonization of central venous catheters in mice. Overall, these preclinical studies suggest that NDV-3A may serve as an immunotherapeutic strategy for prevention of infections on indwelling medical devices.
- Subjects :
- Animals
Antibodies, Fungal immunology
Biofilms drug effects
Candida albicans drug effects
Candida albicans immunology
Cell Adhesion drug effects
Central Venous Catheters microbiology
Fungal Vaccines pharmacology
Humans
Infection Control
Mice
Recombinant Proteins
Antibodies, Fungal pharmacology
Fungal Proteins immunology
Fungal Vaccines therapeutic use
Vaccination methods
Subjects
Details
- Language :
- English
- ISSN :
- 2045-2322
- Volume :
- 9
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Scientific reports
- Publication Type :
- Academic Journal
- Accession number :
- 30996274
- Full Text :
- https://doi.org/10.1038/s41598-019-42517-y