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The metabolic characteristics of susceptibility to wooden breast disease in chickens with high feed efficiency.
- Source :
-
Poultry science [Poult Sci] 2019 Aug 01; Vol. 98 (8), pp. 3246-3256. - Publication Year :
- 2019
-
Abstract
- This study was conducted to characterize metabolic differences between high feed efficiency (HFE) and low feed efficiency (LFE) chickens to investigate why feed efficient chickens are more susceptible to muscle abnormalities such as wooden breast disease. Gene expression profiles were generated by RNA sequencing of pectoralis major muscle samples from 10 HFE and 13 LFE broiler chickens selected from a modern broiler population. Metabolism-associated differentially expressed genes were identified and interpreted by Ingenuity Pathway Analysis and literature mining. Our RNA-seq data indicate decreased glycolytic capacity, increased fatty acid uptake, mitochondrial oxidation of fatty acids, and several other metabolic alterations in the pectoralis major muscle of HFE chickens. We also quantified glycogen content of the pectoralis major muscle and found that the HFE chickens had a significantly (P ≤ 0.05) lower glycogen content. Collectively, this study indicates extensive metabolic differences in the pectoralis major muscle between HFE and LFE chickens and helps identify metabolic features of susceptibility to muscle disorders in modern broiler chickens.<br /> (© 2019 Poultry Science Association Inc.)
- Subjects :
- Animal Nutritional Physiological Phenomena genetics
Animals
Chickens metabolism
Fatty Acids metabolism
Glycogen analysis
Muscular Diseases genetics
Muscular Diseases metabolism
Pectoralis Muscles metabolism
Poultry Diseases metabolism
Sequence Analysis, RNA
Transcriptome
Chickens genetics
Muscular Diseases veterinary
Poultry Diseases genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1525-3171
- Volume :
- 98
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Poultry science
- Publication Type :
- Academic Journal
- Accession number :
- 30995306
- Full Text :
- https://doi.org/10.3382/ps/pez183