Back to Search
Start Over
Longitudinal evaluation of visual function and structure for detection of subclinical Ethambutol-induced optic neuropathy.
- Source :
-
PloS one [PLoS One] 2019 Apr 17; Vol. 14 (4), pp. e0215297. Date of Electronic Publication: 2019 Apr 17 (Print Publication: 2019). - Publication Year :
- 2019
-
Abstract
- Purpose: To longitudinally evaluate the visual function and structure of patients taking ethambutol by various modalities and identify useful tests for detection of subclinical ethambutol-induced optic toxicity.<br />Methods: This retrospective study enrolled 84 patients with newly diagnosed tuberculosis treated with ethambutol. Best-corrected visual acuity (BCVA), color vision, contrast sensitivity, fundus and retinal nerve fiber layer (RNFL) photography, automated visual field (VF) test, and optical coherence tomography (OCT) were performed: prior to starting; every month during administration, and 1 month after stoppage. We longitudinally compared visual function and structure with the baseline and identified the occurrence of subclinical toxicity.<br />Results: BCVA, color vision, and contrast sensitivity showed no change from the baseline. Mean temporal RNFL thickness was significantly increased at 6 months (p = 0.014). Subclinical toxicity was found in 22 eyes of 14 patients (i.e., 13% of 168 eyes), in the forms of VFI decrease (VF index, 9 eyes of 6 patients), quadrant RNFL thickness increase (5 eyes of 4 patients), and VF pattern defect (12 eyes of 6 patients). 73% of the patients showed recovery to the baseline at 1 month post-stoppage. The risk factors for occurrence of subclinical toxicity were age, cumulative dose, and medication duration.<br />Conclusion: Mean temporal RNFL thickness increased after administration. The VFI, quadrant RNFL thickness, and VF pattern defect could prove useful in assessment of subclinical toxicity. Medication duration was shown to be a strong risk factor for occurrence of subclinical toxicity.<br />Competing Interests: The authors have declared that no competing interests exist.
- Subjects :
- Adolescent
Adult
Aged
Aged, 80 and over
Female
Humans
Longitudinal Studies
Male
Middle Aged
Retrospective Studies
Time Factors
Visual Field Tests
Color Perception drug effects
Contrast Sensitivity drug effects
Ethambutol administration & dosage
Ethambutol adverse effects
Tomography, Optical Coherence
Toxic Optic Neuropathy diagnostic imaging
Toxic Optic Neuropathy pathology
Toxic Optic Neuropathy physiopathology
Tuberculosis diagnostic imaging
Tuberculosis drug therapy
Tuberculosis pathology
Tuberculosis physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 1932-6203
- Volume :
- 14
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- PloS one
- Publication Type :
- Academic Journal
- Accession number :
- 30995284
- Full Text :
- https://doi.org/10.1371/journal.pone.0215297