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Optimizing the Diagnosis of Parkinsonian Syndromes With 123 I-Ioflupane Brain SPECT.

Authors :
Banks KP
Peacock JG
Clemenshaw MN
Kuo PH
Source :
AJR. American journal of roentgenology [AJR Am J Roentgenol] 2019 Aug; Vol. 213 (2), pp. 243-253. Date of Electronic Publication: 2019 Apr 17.
Publication Year :
2019

Abstract

OBJECTIVE. The purpose of this article is to provide a review of <superscript>123</superscript> I-ioflupane SPECT in the evaluation of suspected parkinsonian syndromes (PSs). This collection of diseases presents frequent diagnostic challenges, even by movement disorder and dementia specialists. CONCLUSION. The <superscript>123</superscript> I-ioflupane scan serves as an imaging biomarker of the status of presynaptic dopamine transporters (DATs) in the striatum. As a result of neuronal death, DATs are greatly reduced in patients with PS neurodegenerative disorders, whereas clinical mimics generally do not show striatal DAT loss. This provides a tremendous opportunity for <superscript>123</superscript> I-ioflupane to aid in the accurate and timely diagnosis of these patients and optimize their management.

Details

Language :
English
ISSN :
1546-3141
Volume :
213
Issue :
2
Database :
MEDLINE
Journal :
AJR. American journal of roentgenology
Publication Type :
Academic Journal
Accession number :
30995085
Full Text :
https://doi.org/10.2214/AJR.19.21088