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Optimizing the Diagnosis of Parkinsonian Syndromes With 123 I-Ioflupane Brain SPECT.
- Source :
-
AJR. American journal of roentgenology [AJR Am J Roentgenol] 2019 Aug; Vol. 213 (2), pp. 243-253. Date of Electronic Publication: 2019 Apr 17. - Publication Year :
- 2019
-
Abstract
- OBJECTIVE. The purpose of this article is to provide a review of <superscript>123</superscript> I-ioflupane SPECT in the evaluation of suspected parkinsonian syndromes (PSs). This collection of diseases presents frequent diagnostic challenges, even by movement disorder and dementia specialists. CONCLUSION. The <superscript>123</superscript> I-ioflupane scan serves as an imaging biomarker of the status of presynaptic dopamine transporters (DATs) in the striatum. As a result of neuronal death, DATs are greatly reduced in patients with PS neurodegenerative disorders, whereas clinical mimics generally do not show striatal DAT loss. This provides a tremendous opportunity for <superscript>123</superscript> I-ioflupane to aid in the accurate and timely diagnosis of these patients and optimize their management.
Details
- Language :
- English
- ISSN :
- 1546-3141
- Volume :
- 213
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- AJR. American journal of roentgenology
- Publication Type :
- Academic Journal
- Accession number :
- 30995085
- Full Text :
- https://doi.org/10.2214/AJR.19.21088