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The development and characterization of Propranolol Tablets using Tapioca starch as excipient.
- Source :
-
Anais da Academia Brasileira de Ciencias [An Acad Bras Cienc] 2019; Vol. 91 (1), pp. e20180094. Date of Electronic Publication: 2019 Apr 08. - Publication Year :
- 2019
-
Abstract
- Tapioca starch (TS) is produced from Cassaca roots and it is differentiated from other starches because it contains about 17-20% amylase and low amount of residual substances. Propranolol (POP) is a non-selective beta-adrenergic blocking agent and it is in the World Health Organization's List of Essential Medicines. The aim of this work was to investigate the potential of TS in the development of POP tablets by means of direct compression. Its evaluation was performed by X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), Nuclear Magnetic Resonance (NMR) relaxometry, scanning electron microscopy (SEM), uniformity of weight, drug content, disintegration, friability, hardness, dissolution test and drug release kinetics. The TS granules were spherical with mean diameter of 10.09 ± 1.85 µm. The XRD, FTIR and NMR suggested physical interaction between TS and POP. The tablets presented average diameter of 1.1 ± 0.0 cm, 0.24 ± 0.02 cm thickness and average weight of 0.544 ± 0.003 g. The hardness of tablets was 10.98 ± 0.31 N and the percentage of friability was 25.74 ± 0.08%. POP was released after 45 min and the release kinetics properly fitted the Hixson-Crowell equation.
- Subjects :
- Drug Design
Hardness Tests
Magnetic Resonance Spectroscopy
Materials Testing
Microscopy, Electron, Scanning
Particle Size
Reference Values
Reproducibility of Results
Spectroscopy, Fourier Transform Infrared
Time Factors
X-Ray Diffraction
Adrenergic beta-Antagonists chemistry
Excipients chemistry
Manihot chemistry
Propranolol chemistry
Starch chemistry
Tablets chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1678-2690
- Volume :
- 91
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Anais da Academia Brasileira de Ciencias
- Publication Type :
- Academic Journal
- Accession number :
- 30994758
- Full Text :
- https://doi.org/10.1590/0001-3765201920180094