Melatonin benefits to the growth of human annulus fibrosus cells through inhibiting miR-106a-5p/ATG7 signaling pathway.

Authors :: Hai B
Ma Y
Pan X
Yong L
Liang C
He G
Yang C
Zhu B
Liu X
Source :: Clinical interventions in aging [Clin Interv Aging] 2019 Mar 28; Vol. 14, pp. 621-630. Date of Electronic Publication: 2019 Mar 28 (Print Publication: 2019).
Publication Year :: 2019
Abstract: Background: Disc degeneration (DD) is one of the common diseases worldwide, which deeply influences normal life and leads to excruciating pain. However, an effective treatment for DD is still not identified.<br />Method: The present study systemically examined the effect of melatonin on annulus fibrosus (AF) cells of patients with DD.<br />Results: Melatonin had the effect of promoting proliferation, inducing autophagy, and suppressing apoptosis on AF cells of patients with DD. Moreover, melatonin contributed to the translation and transcription of autophagy-related protein ATG7 and inhibited the function of miR-106a-5p in AF cells. In addition, the results suggested that miR-106a-5p mediated the expression of ATG7 by directly binding to its 3'UTR in AF cells.<br />Conclusion: This research not only gained a deep insight of melatonin mode of action, but also indicated its potential target signaling pathway in AF cells.<br />Competing Interests: Disclosure The authors report no conflicts of interest in this work.

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