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Topical sirolimus therapy for epidermal nevus with features of acanthosis nigricans.
- Source :
-
Pediatric dermatology [Pediatr Dermatol] 2019 Jul; Vol. 36 (4), pp. 554-555. Date of Electronic Publication: 2019 Apr 15. - Publication Year :
- 2019
-
Abstract
- We present a 4-year-old developmentally appropriate boy with short stature and widespread expanding epidermal nevus with features of acanthosis nigricans. He was found to have a mosaic mutation in FGFR3, the R248C variant. Despite several therapies, he continued to have growth, fissuring, and bleeding of the affected skin. Ultimately, topical sirolimus was attempted and found to improve thickness and overall symptoms.<br /> (© 2019 Wiley Periodicals, Inc.)
- Subjects :
- Acanthosis Nigricans genetics
Administration, Topical
Child, Preschool
Diagnosis, Differential
Gene Expression Regulation
Humans
Male
Mutation
Nevus pathology
Risk Assessment
Treatment Outcome
Acanthosis Nigricans pathology
Nevus drug therapy
Nevus genetics
Receptor, Fibroblast Growth Factor, Type 3 genetics
Sirolimus therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1525-1470
- Volume :
- 36
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Pediatric dermatology
- Publication Type :
- Academic Journal
- Accession number :
- 30983034
- Full Text :
- https://doi.org/10.1111/pde.13833