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A non-death function of the mitochondrial apoptosis apparatus in immunity.
- Source :
-
The EMBO journal [EMBO J] 2019 Jun 03; Vol. 38 (11). Date of Electronic Publication: 2019 Apr 12. - Publication Year :
- 2019
-
Abstract
- Apoptosis is a frequent form of programmed cell death, but the apoptotic signaling pathway can also be engaged at a low level, in the absence of cell death. We here report that such sub-lethal engagement of mitochondrial apoptosis signaling causes the secretion of cytokines from human epithelial cells in a process controlled by the Bcl-2 family of proteins. We further show that sub-lethal signaling of the mitochondrial apoptosis pathway is initiated by infections with all tested viral, bacterial, and protozoan pathogens and causes damage to the genomic DNA. Epithelial cells infected with these pathogens secreted cytokines, and this cytokine secretion upon microbial infection was substantially reduced if mitochondrial sub-lethal apoptosis signaling was blocked. In the absence of mitochondrial pro-apoptotic signaling, the ability of epithelial cells to restrict intracellular bacterial growth was impaired. Triggering of the mitochondrial apoptosis apparatus thus not only causes apoptosis but also has an independent role in immune defense.<br /> (© 2019 The Authors.)
- Subjects :
- Animals
Cell Death immunology
Cells, Cultured
Epithelial Cells physiology
HCT116 Cells
HEK293 Cells
HeLa Cells
Humans
Mice
Proto-Oncogene Proteins c-bcl-2 physiology
Serine Endopeptidases physiology
Signal Transduction physiology
bcl-2 Homologous Antagonist-Killer Protein physiology
bcl-2-Associated X Protein physiology
Apoptosis physiology
Immunity physiology
Mitochondria physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1460-2075
- Volume :
- 38
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- The EMBO journal
- Publication Type :
- Academic Journal
- Accession number :
- 30979778
- Full Text :
- https://doi.org/10.15252/embj.2018100907