Back to Search
Start Over
Feedforward regulation of Myc coordinates lineage-specific with housekeeping gene expression during B cell progenitor cell differentiation.
- Source :
-
PLoS biology [PLoS Biol] 2019 Apr 12; Vol. 17 (4), pp. e2006506. Date of Electronic Publication: 2019 Apr 12 (Print Publication: 2019). - Publication Year :
- 2019
-
Abstract
- The differentiation of self-renewing progenitor cells requires not only the regulation of lineage- and developmental stage-specific genes but also the coordinated adaptation of housekeeping functions from a metabolically active, proliferative state toward quiescence. How metabolic and cell-cycle states are coordinated with the regulation of cell type-specific genes is an important question, because dissociation between differentiation, cell cycle, and metabolic states is a hallmark of cancer. Here, we use a model system to systematically identify key transcriptional regulators of Ikaros-dependent B cell-progenitor differentiation. We find that the coordinated regulation of housekeeping functions and tissue-specific gene expression requires a feedforward circuit whereby Ikaros down-regulates the expression of Myc. Our findings show how coordination between differentiation and housekeeping states can be achieved by interconnected regulators. Similar principles likely coordinate differentiation and housekeeping functions during progenitor cell differentiation in other cell lineages.<br />Competing Interests: The authors have declared that no competing interests exist.
- Subjects :
- Animals
B-Lymphocytes metabolism
Cell Cycle physiology
Cell Differentiation genetics
Cell Lineage
Databases, Genetic
Down-Regulation
Gene Expression Regulation
Genes, Essential
Humans
Ikaros Transcription Factor metabolism
Lymphocyte Activation
Mice
Precursor Cells, B-Lymphoid metabolism
Transcription Factors metabolism
B-Lymphocytes cytology
Genes, myc
Precursor Cells, B-Lymphoid cytology
Subjects
Details
- Language :
- English
- ISSN :
- 1545-7885
- Volume :
- 17
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- PLoS biology
- Publication Type :
- Academic Journal
- Accession number :
- 30978178
- Full Text :
- https://doi.org/10.1371/journal.pbio.2006506