Back to Search
Start Over
Long-term Results of Mini Asymmetric Radial Keratotomy and Corneal Cross-linking for the Treatment of Keratoconus.
- Source :
-
Korean journal of ophthalmology : KJO [Korean J Ophthalmol] 2019 Apr; Vol. 33 (2), pp. 189-195. - Publication Year :
- 2019
-
Abstract
- Purpose: To investigate the long-term results (at least 5 years of follow-up) of the mini asymmetric radial keratotomy (MARK) and corneal cross-linking (CXL) combined intervention, also known as the 'Rome protocol,' for patients with progressive stage I and II keratoconus and contact lens intolerance.<br />Methods: This was a retrospective observational case series. Fifteen eyes of 12 patients were evaluated, with a mean follow-up of 6.9 years. To assess the efficacy and stability of the MARK + CXL combined protocol, best spectacle-corrected visual acuity, mean pachymetry, and mean keratometry were recorded preoperatively and at least 1, 3, and 5 years postoperatively. Statistical analysis was performed using the R platform and involved the Wilcoxon signed-rank and Kruskal-Wallis non-parametric tests.<br />Results: Best spectacle-corrected visual acuity improved for all patients, from 0.46 ± 0.69 logarithm of the minimum angle of resolution (20 / 60) to 0.15 ± 0.69 logarithm of the minimum angle of resolution (20 / 30, p = 0.0006), while mean pachymetry increased in 93% of patients, from 442.80 ± 61.02 to 464.50 ± 62.72 μm ( p = 0.003). Lastly, mean keratometry improved in 87% of patients after 6.9 years of observation from 48.82 ± 5.00 to 43.25 ± 3.58 diopters ( p = 0.008). No intraoperative or postoperative complications were observed.<br />Conclusions: The MARK + CXL combined protocol was effective in treating keratoconus by halting corneal thinning and bulging. In addition, this procedure significantly improved visual acuity based on long-term follow-up data. Analysis of data from a larger cohort of patients would be useful to support these findings.<br />Competing Interests: No potential conflict of interest relevant to this article was reported.<br /> (© 2019 The Korean Ophthalmological Society.)
- Subjects :
- Adult
Cornea drug effects
Cornea pathology
Cornea surgery
Corneal Topography
Female
Follow-Up Studies
Humans
Keratoconus diagnosis
Male
Photochemotherapy methods
Retrospective Studies
Time Factors
Treatment Outcome
Collagen therapeutic use
Cross-Linking Reagents therapeutic use
Keratoconus therapy
Keratotomy, Radial methods
Photosensitizing Agents therapeutic use
Refraction, Ocular
Visual Acuity
Subjects
Details
- Language :
- English
- ISSN :
- 2092-9382
- Volume :
- 33
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Korean journal of ophthalmology : KJO
- Publication Type :
- Academic Journal
- Accession number :
- 30977329
- Full Text :
- https://doi.org/10.3341/kjo.2018.0028