Back to Search
Start Over
Age-specific differences in the dynamics of protective immunity to influenza.
- Source :
-
Nature communications [Nat Commun] 2019 Apr 10; Vol. 10 (1), pp. 1660. Date of Electronic Publication: 2019 Apr 10. - Publication Year :
- 2019
-
Abstract
- Influenza A viruses evolve rapidly to escape host immunity, causing reinfection. The form and duration of protection after each influenza virus infection are poorly understood. We quantify the dynamics of protective immunity by fitting individual-level mechanistic models to longitudinal serology from children and adults. We find that most protection in children but not adults correlates with antibody titers to the hemagglutinin surface protein. Protection against circulating strains wanes to half of peak levels 3.5-7 years after infection in both age groups, and wanes faster against influenza A(H3N2) than A(H1N1)pdm09. Protection against H3N2 lasts longer in adults than in children. Our results suggest that influenza antibody responses shift focus with age from the mutable hemagglutinin head to other epitopes, consistent with the theory of original antigenic sin, and might affect protection. Imprinting, or primary infection with a subtype, has modest to no effect on the risk of non-medically attended infections in adults.
- Subjects :
- Adolescent
Adult
Age Factors
Aged
Antibodies, Viral immunology
Antigens, Viral immunology
Antigens, Viral isolation & purification
Child
Child, Preschool
Female
Follow-Up Studies
Hemagglutinins immunology
Hong Kong epidemiology
Humans
Incidence
Influenza A Virus, H1N1 Subtype immunology
Influenza A Virus, H1N1 Subtype isolation & purification
Influenza A Virus, H3N2 Subtype immunology
Influenza A Virus, H3N2 Subtype isolation & purification
Influenza Vaccines administration & dosage
Influenza Vaccines immunology
Influenza, Human epidemiology
Influenza, Human prevention & control
Influenza, Human virology
Longitudinal Studies
Male
Middle Aged
Randomized Controlled Trials as Topic
Time Factors
Young Adult
Antibodies, Viral blood
Cross Protection immunology
Immunologic Memory immunology
Influenza, Human immunology
Models, Biological
Subjects
Details
- Language :
- English
- ISSN :
- 2041-1723
- Volume :
- 10
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Nature communications
- Publication Type :
- Academic Journal
- Accession number :
- 30971703
- Full Text :
- https://doi.org/10.1038/s41467-019-09652-6