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Second near-infrared photodynamic therapy and chemotherapy of orthotopic malignant glioblastoma with ultra-small Cu 2-x Se nanoparticles.
- Source :
-
Nanoscale [Nanoscale] 2019 Apr 23; Vol. 11 (16), pp. 7600-7608. - Publication Year :
- 2019
-
Abstract
- The treatment of malignant glioblastoma is a huge challenge due to the existence of the blood-brain barrier. Herein, we report the treatment of orthotopic malignant glioblastoma with imaging guided second near-infrared (NIR-II) photodynamic therapy and chemotherapy by using drug-loaded ultra-small Cu2-xSe theranostic nanoparticles (NPs). Ultra-small Cu2-xSe NPs possess a strong absorbance in the NIR-II window, and their absorption at 1064 nm is around 2 times that at 808 nm. Their strong NIR-II absorbance and the deeper-tissue penetration of NIR-II light ensure excellent photodynamic therapy performance under irradiation with a 1064 nm laser. We also demonstrate that ultra-small Cu2-xSe NPs can produce vast amounts of reactive oxygen species via electron transfer (for ˙OH generation) and energy transfer (for 1O2 generation) mechanisms under irradiation. In addition, these NPs can be effectively and locally transported into orthotopic malignant glioblastoma with the assistance of focused ultrasound. The deposited Cu2-xSe NPs can be used for photoacoustic imaging to guide the combined NIR-II photodynamic therapy and chemotherapy. The results show that the tumor growth can be significantly suppressed. This work demonstrates the great potential of drug-loaded ultra-small Cu2-xSe NPs as a promising therapeutic agent for the treatment of orthotopic malignant glioblastoma.
- Subjects :
- Animals
Brain pathology
Cell Line, Tumor
Cell Survival drug effects
Glioblastoma drug therapy
Glioblastoma mortality
Glioblastoma pathology
Humans
Mice
Mice, Nude
Nanoparticles therapeutic use
Nanoparticles toxicity
Photochemotherapy
Singlet Oxygen chemistry
Singlet Oxygen metabolism
Survival Rate
Transplantation, Heterologous
Copper chemistry
Infrared Rays
Nanoparticles chemistry
Selenium chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 2040-3372
- Volume :
- 11
- Issue :
- 16
- Database :
- MEDLINE
- Journal :
- Nanoscale
- Publication Type :
- Academic Journal
- Accession number :
- 30968107
- Full Text :
- https://doi.org/10.1039/c9nr01789e