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Resting-state connectivity of the bed nucleus of the stria terminalis and the central nucleus of the amygdala in clinical anxiety
- Source :
-
Journal of psychiatry & neuroscience : JPN [J Psychiatry Neurosci] 2019 Sep 01; Vol. 44 (5), pp. 313-323. - Publication Year :
- 2019
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Abstract
- Background: The central nucleus of the amygdala and bed nucleus of the stria terminalis are involved primarily in phasic and sustained aversive states. Although both structures have been implicated in pathological anxiety, few studies with a clinical population have specifically focused on them, partly because of their small size. Previous work in our group used high-resolution imaging to map the restingstate functional connectivity of the bed nucleus of the stria terminalis and the central nucleus of the amygdala in healthy subjects at 7 T, confirming and extending structural findings in humans and animals, while providing additional insight into cortical connectivity that is potentially unique to humans.<br />Methods: In the current follow-up study, we contrasted resting-state functional connectivity in the bed nucleus of the stria terminalis and central nucleus of the amygdala at 7 T between healthy volunteers (n = 30) and patients with generalized and/or social anxiety disorder (n = 30).<br />Results: Results revealed significant voxel-level group differences. Compared with healthy volunteers, patients showed stronger resting-state functional connectivity between the central nucleus of the amygdala and the lateral orbitofrontal cortex and superior temporal sulcus. They also showed weaker resting-state functional connectivity between the bed nucleus of the stria terminalis and the dorsolateral prefrontal cortex and occipital cortex.<br />Limitations: These findings depart from a previous report of resting-state functional connectivity in the central nucleus of the amygdala and bed nucleus of the stria terminalis under sustained threat of shock in healthy volunteers.<br />Conclusion: This study provides functional MRI proxies of the functional dissociation of the bed nucleus of the stria terminalis and central nucleus of the amygdala, and suggests that resting-state functional connectivity of key structures in the processing of defensive responses do not recapitulate changes related to induced state anxiety. Future work needs to replicate and further probe the clinical significance of these findings.<br />Competing Interests: None declared.<br /> (© 2019 Joule Inc. or its licensors)
- Subjects :
- Adult
Anxiety Disorders physiopathology
Anxiety Disorders psychology
Case-Control Studies
Central Amygdaloid Nucleus physiopathology
Cerebral Cortex physiopathology
Female
Functional Neuroimaging
Humans
Magnetic Resonance Imaging
Male
Neural Pathways diagnostic imaging
Neural Pathways physiopathology
Occipital Lobe diagnostic imaging
Occipital Lobe physiopathology
Phobia, Social physiopathology
Phobia, Social psychology
Prefrontal Cortex diagnostic imaging
Prefrontal Cortex physiopathology
Septal Nuclei physiopathology
Temporal Lobe diagnostic imaging
Temporal Lobe physiopathology
Young Adult
Anxiety Disorders diagnostic imaging
Central Amygdaloid Nucleus diagnostic imaging
Cerebral Cortex diagnostic imaging
Phobia, Social diagnostic imaging
Septal Nuclei diagnostic imaging
Subjects
Details
- Language :
- English
- ISSN :
- 1488-2434
- Volume :
- 44
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Journal of psychiatry & neuroscience : JPN
- Publication Type :
- Academic Journal
- Accession number :
- 30964612
- Full Text :
- https://doi.org/10.1503/jpn.180150