Back to Search
Start Over
Nanowired delivery of DL-3-n-butylphthalide induces superior neuroprotection in concussive head injury.
- Source :
-
Progress in brain research [Prog Brain Res] 2019; Vol. 245, pp. 89-118. Date of Electronic Publication: 2019 Apr 02. - Publication Year :
- 2019
-
Abstract
- Concussive head injury (CHI) is quite prevalent in military personnel leading to lifetime disability in more than 85% of cases. Other reasons of CHI include motor vehicle accident, fall or blunt trauma under various conditions. In United States of America (USA) alone more than 150k cases of head injury are added every year for which no suitable therapeutic strategies are still available. Thus, there is a need to expand our knowledge in treating CHI cases with novel therapeutic measures to enhance the quality of life of head injury victims. With recent advancements in nanodelivery of drugs for superior neuroprotective effects in neurological diseases, our laboratory is engaged in understanding the role of nanowired delivery of suitable drugs in treating CHI and other neurodegenerative diseases. DL-3-n-butylphthalide (NBP) is an extract of Chinese celery and is able to induce profound neuroprotection following ischemic stroke and other related neurological dysfunction. Thus, it is quite likely that synthetic NBP could have pronounced neuroprotective effects in CHI as well. We believe that nanodelivery of NBP have superior neuroprotection in CHI. In this review neuroprotective effects of nanowired delivery of NBP in CHI induced brain pathology is described. Our experimental observations show that nanowired delivery of NBP results in superior neuroprotection than the regular NBP in CHI. The probable mechanisms and functional significance of our finding in relation to military medicine is discussed based on our own investigations.<br /> (© 2019 Elsevier B.V. All rights reserved.)
- Subjects :
- Animals
Brain Concussion complications
Brain Concussion pathology
Brain Edema etiology
Brain Edema pathology
Humans
Benzofurans administration & dosage
Brain Concussion drug therapy
Brain Edema drug therapy
Nanomedicine methods
Nanowires therapeutic use
Neuroprotective Agents administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 1875-7855
- Volume :
- 245
- Database :
- MEDLINE
- Journal :
- Progress in brain research
- Publication Type :
- Academic Journal
- Accession number :
- 30961873
- Full Text :
- https://doi.org/10.1016/bs.pbr.2019.03.008