Lithocarols A-F, six tenellone derivatives from the deep-sea derived fungus Phomopsis lithocarpus FS508.

Authors :: Xu J
Liu Z
Chen Y
Tan H
Li H
Li S
Guo H
Huang Z
Gao X
Liu H
Zhang W
Source :: Bioorganic chemistry [Bioorg Chem] 2019 Jun; Vol. 87, pp. 728-735. Date of Electronic Publication: 2019 Apr 01.
Publication Year :: 2019
Abstract: Lithocarols A-F (1-6) possessing novel highly-oxygenated isobenzofuran core, together with a related known compound isoprenylisobenzofuran A (7) were isolated from the marine-derived fungus Phomopsis lithocarpus FS508. Among them, lithocarols A-E (1-5) represent the first examples of poly-ketal derivatives in tenellone family. The structures for all these compounds were fully elucidated by spectroscopic analysis, X-ray diffraction, and electronic circular dichroism calculations. Their cytotoxic assay disclosed that compounds 1-4 displayed moderate growth inhibitory effect against four human tumor cell lines with the IC <subscript>50</subscript> values ranging from 10.5 to 38.7 μM.<br /> (Copyright © 2019 Elsevier Inc. All rights reserved.)

Subjects :: Antineoplastic Agents chemistry
Antineoplastic Agents isolation & purification
Benzofurans chemistry
Benzofurans isolation & purification
Cell Line, Tumor
Cell Proliferation drug effects
Crystallography, X-Ray
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
Humans
Models, Molecular
Molecular Structure
Structure-Activity Relationship
Antineoplastic Agents pharmacology
Ascomycota chemistry
Benzofurans pharmacology

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