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Second primary malignancies in laryngeal carcinoma patients treated with definitive radiotherapy.
- Source :
-
Indian journal of cancer [Indian J Cancer] 2019 Jan-Mar; Vol. 56 (1), pp. 29-34. - Publication Year :
- 2019
-
Abstract
- Introduction: Second primary malignancy (SPM) is associated with decreased overall survival (OS) in laryngeal carcinomas (LC).<br />Methods: One hundred eighty three LC patients were analyzed retrospectively. The primary and secondary endpoints were the incidence of SPM and the OS difference between patients with and without SPM.<br />Results: SPM developed in 22 (12.0%) patients at median 52 months (range, 4-131 months), with a yearly 2.8% incidence, of which 19 (10.4%) and 3 (1.6%) were metachronous and synchronous, respectively. Lung was the commonest SPM (72.7%). Of 47 deaths, 12 (25.5%) were SPM related. Comparatively SPM patients had significantly shorter median OS (68.0 months vs. median not reached; P = 0.005), with lower 5-year (67.0% vs. 78.9%) and 8-year (32.6 vs. 69.8%) survival rates.<br />Conclusion: The present findings suggested the SPM as a competing risk factor for death in index LC patients with its annual incidence rate of 2.8% and for accounting one of every four deaths in this patients group. Emergence of lung carcinoma as the most frequent type of SPM and the ability to treat >50% of them with an estimated long-term outcomes emphasizes the importance of early diagnosis and curative treatment of SPMs.<br />Competing Interests: There are no conflicts of interest.
- Subjects :
- Adult
Aged
Aged, 80 and over
Carcinoma, Squamous Cell pathology
Female
Follow-Up Studies
Humans
Incidence
Laryngeal Neoplasms pathology
Male
Middle Aged
Neoplasms, Second Primary epidemiology
Prognosis
Retrospective Studies
Risk Factors
Survival Rate
Turkey epidemiology
Carcinoma, Squamous Cell radiotherapy
Laryngeal Neoplasms radiotherapy
Neoplasms, Second Primary etiology
Radiotherapy adverse effects
Radiotherapy mortality
Subjects
Details
- Language :
- English
- ISSN :
- 1998-4774
- Volume :
- 56
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Indian journal of cancer
- Publication Type :
- Academic Journal
- Accession number :
- 30950440
- Full Text :
- https://doi.org/10.4103/ijc.IJC_273_18