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Tuberculosis vaccine candidates based on mycobacterial cell envelope components.
- Source :
-
Tuberculosis (Edinburgh, Scotland) [Tuberculosis (Edinb)] 2019 Mar; Vol. 115, pp. 26-41. Date of Electronic Publication: 2019 Jan 22. - Publication Year :
- 2019
-
Abstract
- Even after decades searching for a new and more effective vaccine against tuberculosis, the scientific community is still pursuing this goal due to the complexity of its causative agent, Mycobacterium tuberculosis (Mtb). Mtb is a microorganism with a robust variety of survival mechanisms that allow it to remain in the host for years. The structure and nature of the Mtb envelope play a leading role in its resistance and survival. Mtb has a perfect machinery that allows it to modulate the immune response in its favor and to adapt to the host's environmental conditions in order to remain alive until the moment to reactivate its normal growing state. Mtb cell envelope protein, carbohydrate and lipid components have been the subject of interest for developing new vaccines because most of them are responsible for the pathogenicity and virulence of the bacteria. Many indirect evidences, mainly derived from the use of monoclonal antibodies, support the potential protective role of Mtb envelope components. Subunit and DNA vaccines, lipid extracts, liposomes and membrane vesicle formulations are some examples of technologies used, with encouraging results, to evaluate the potential of these antigens in the protective response against Mtb.<br /> (Copyright © 2019. Published by Elsevier Ltd.)
- Subjects :
- Animals
Antibodies, Bacterial immunology
Antibodies, Monoclonal immunology
BCG Vaccine chemistry
Bacterial Capsules chemistry
Bacterial Capsules physiology
Bacterial Proteins metabolism
Cell Membrane physiology
Cell Wall physiology
Cord Factors physiology
Humans
Mice
Mycobacterium tuberculosis immunology
Mycobacterium tuberculosis pathogenicity
Virulence physiology
Tuberculosis prevention & control
Tuberculosis Vaccines
Subjects
Details
- Language :
- English
- ISSN :
- 1873-281X
- Volume :
- 115
- Database :
- MEDLINE
- Journal :
- Tuberculosis (Edinburgh, Scotland)
- Publication Type :
- Academic Journal
- Accession number :
- 30948174
- Full Text :
- https://doi.org/10.1016/j.tube.2019.01.003