Back to Search
Start Over
MoS 2 flakes stabilized with DNA/RNA nucleotides: In vitro cell response.
- Source :
-
Materials science & engineering. C, Materials for biological applications [Mater Sci Eng C Mater Biol Appl] 2019 Jul; Vol. 100, pp. 11-22. Date of Electronic Publication: 2019 Feb 07. - Publication Year :
- 2019
-
Abstract
- Two-dimensional transition metal dichalcogenides (TMDCs), such as MoS <subscript>2</subscript> and WS <subscript>2</subscript> , have recently emerged as nanomaterials with potential use in biomedicine. An attractive means to favor their interaction with biological media is the use of proper biomolecules as exfoliating/dispersing agents. Here, MoS <subscript>2</subscript> flakes were stabilized with different small functional biomolecules such as adenosine monophosphate (AMP), guanosine monophosphate (GMP) and flavin mononucleotide (FMN) through the strong nucleotide-MoS <subscript>2</subscript> interaction of Lewis acid-base type, rather than just on the weak dispersive and hydrophobic forces commonly associated with the use of many surfactants. The impact of the nucleotide-stabilized MoS <subscript>2</subscript> flakes on the viability and cell proliferation, on the production of intracellular reactive oxygen species (ROS), and on the preosteoblast differentiation process (early stage) has been also evaluated, as well as the incorporation and intracellular localization of the nanomaterials by MC3T3-E1 and Saos-2 cells. The nucleotide-stabilized MoS <subscript>2</subscript> flakes were found to exhibit excellent biocompatibility. Furthermore, their incorporation did not affect the integrity of the cell plasma membrane, which makes them ideal candidates for delivering drug/gene directly into cells. The in vitro cell response of tumor cells to these nanomaterials differs from that of undifferentiated cells, which provides the basis for their potential use in cancer therapy.<br /> (Copyright © 2019. Published by Elsevier B.V.)
- Subjects :
- Animals
Biocompatible Materials chemistry
Biocompatible Materials pharmacology
Cell Line
Cell Survival drug effects
Humans
Mice
Nanostructures toxicity
Osteoblasts cytology
Osteoblasts drug effects
Osteoblasts metabolism
Reactive Oxygen Species metabolism
Adenosine Monophosphate chemistry
Disulfides chemistry
Flavin Mononucleotide chemistry
Guanosine Monophosphate chemistry
Molybdenum chemistry
Nanostructures chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1873-0191
- Volume :
- 100
- Database :
- MEDLINE
- Journal :
- Materials science & engineering. C, Materials for biological applications
- Publication Type :
- Academic Journal
- Accession number :
- 30948045
- Full Text :
- https://doi.org/10.1016/j.msec.2019.02.002