Optimizing thiopurine dosing based on TPMT and NUDT15 genotypes: It takes two to tango.

Authors :: Koutsilieri S
Caudle KE
Alzghari SK
Monte AA
Relling MV
Patrinos GP
Source :: American journal of hematology [Am J Hematol] 2019 Jul; Vol. 94 (7), pp. 737-740. Date of Electronic Publication: 2019 Apr 10.
Publication Year :: 2019

Subjects :: Female
Humans
Male
Genotype
Leukemia drug therapy
Leukemia genetics
Leukemia metabolism
Leukemia pathology
Mercaptopurine analogs & derivatives
Mercaptopurine therapeutic use
Methyltransferases genetics
Methyltransferases metabolism
Pyrophosphatases genetics
Pyrophosphatases metabolism
Thioguanine therapeutic use

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