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Mucocutaneous manifestations in systemic amyloidosis A retrospective analytical study in a tertiary care center.
- Source :
-
International journal of dermatology [Int J Dermatol] 2019 Sep; Vol. 58 (9), pp. 1062-1068. Date of Electronic Publication: 2019 Apr 02. - Publication Year :
- 2019
-
Abstract
- Background: The mucocutaneous clinical profile of patients with amyloidosis in Latin America has been scarcely reported.<br />Objective: To describe clinical characteristics of skin and mucosal manifestations in systemic amyloidosis in a tertiary care center in Mexico City.<br />Methods: A cross sectional, retrospective analytical study was performed in patients with systemic amyloidosis over a 15-year period. Statistical analysis was done.<br />Results: A total of 98 patients were included (53 [54%] men; overall median age = 49 years old). Acquired systemic immunoglobulin light chain amyloidosis (AL) was the most common (49%) type, followed by (24.5%) wild-type transthyretin amyloidosis (H-TTR) (24.5%), undetermined cases (21%), and reactive systemic amyloidosis (AA) (6.1%). There were mucocutaneous manifestations in 34.7% of cases, mostly multiple myeloma-related AL (ALMM). Head and neck was the most often affected site (38.2%), and purpuric macules were the most common morphology (44.1%). Mucocutaneous affectation was predominantly observed in AL (50.0%) compared to other types (20.0%) of amyloidosis (P = 0.01). Likewise, involvement of organs was also significantly different among the diverse amyloidosis types (P < 0.05). The most frequent comorbidities were hypertension (18.3%) and hypothyroidism (18.3%).<br />Conclusion: The clinical spectrum of manifestations in amyloidosis is wide. Involvement of skin and mucosa in amyloidosis is common; significant differences were observed concerning distribution of mucocutaneous amyloid manifestations among the different types of amyloidosis.<br /> (© 2019 The International Society of Dermatology.)
- Subjects :
- Adult
Aged
Aged, 80 and over
Comorbidity
Cross-Sectional Studies
Female
Humans
Hypertension epidemiology
Hypothyroidism epidemiology
Immunoglobulin Light-chain Amyloidosis epidemiology
Male
Mexico epidemiology
Middle Aged
Multiple Myeloma epidemiology
Retrospective Studies
Tertiary Care Centers statistics & numerical data
Immunoglobulin Light-chain Amyloidosis pathology
Mucous Membrane pathology
Multiple Myeloma pathology
Skin pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1365-4632
- Volume :
- 58
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- International journal of dermatology
- Publication Type :
- Academic Journal
- Accession number :
- 30941743
- Full Text :
- https://doi.org/10.1111/ijd.14443