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Comparison of long-term oncologic outcomes between metastatic ovarian carcinoma originating from gastrointestinal organs and advanced mucinous ovarian carcinoma.
- Source :
-
International journal of clinical oncology [Int J Clin Oncol] 2019 Aug; Vol. 24 (8), pp. 950-956. Date of Electronic Publication: 2019 Apr 02. - Publication Year :
- 2019
-
Abstract
- Background: Occasionally, ovarian tumors are found to have originated from non-ovarian organs as metastatic lesions since the ovary is a common site of metastasis from many cancers. The aim of the current study was to estimate the long-term oncologic outcome of patients with metastatic mucinous ovarian carcinoma (MmOC) in comparison with those with primary mucinous ovarian carcinoma (PmOC) at an advanced stage.<br />Materials and Methods: The data of one hundred and sixty-seven patients with mucinous ovarian cancer, including 91 patients with MmOC from the digestive organs and 76 patients with stage III-IV PmOC, were retrospectively analyzed. The prognostic significances of clinicopathologic factors were evaluated employing both uni- and multivariable analyses. Pathological slides were evaluated based on centralized pathological review.<br />Results: The median age of patients with PmOC and MmOC was 55 (18-81) and 51 years (30-82), respectively. With follow-up of a total of 167 patients, 145 patients (86.8%) developed recurrence. In addition, 122 patients (73.0%) died of the disease. Regardless of the residual tumor status, patients with PmOC did not a show a significantly poorer OS than those with MmOC. Furthermore, in a Cox multivariable hazard model, after adjustment for various clinicopathologic confounders, a gastric cancer (GC)-originated tumor and larger residual tumor were significant predictors of poorer OS [GC (vs. PmOC): HR (95% CI) 2.205 (1.303-3.654), Pā=ā0.0036].<br />Conclusion: The oncologic outcome of patients with MmOC was extremely poor; however, it was almost the same as that of those with PmOC. We should recognize MmOC derived from gastric carcinoma as a highly aggressive malignancy.
- Subjects :
- Adenocarcinoma, Mucinous pathology
Adenocarcinoma, Mucinous secondary
Adenocarcinoma, Mucinous surgery
Adolescent
Adult
Aged
Aged, 80 and over
Female
Humans
Middle Aged
Neoplasm Recurrence, Local pathology
Neoplasm Recurrence, Local surgery
Ovarian Neoplasms pathology
Ovarian Neoplasms surgery
Prognosis
Retrospective Studies
Survival Rate
Young Adult
Adenocarcinoma, Mucinous mortality
Neoplasm Recurrence, Local mortality
Ovarian Neoplasms mortality
Subjects
Details
- Language :
- English
- ISSN :
- 1437-7772
- Volume :
- 24
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- International journal of clinical oncology
- Publication Type :
- Academic Journal
- Accession number :
- 30941534
- Full Text :
- https://doi.org/10.1007/s10147-019-01438-6