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Transplantation of neuregulin 4-overexpressing adipose-derived mesenchymal stem cells ameliorates insulin resistance by attenuating hepatic steatosis.
- Source :
-
Experimental biology and medicine (Maywood, N.J.) [Exp Biol Med (Maywood)] 2019 May; Vol. 244 (7), pp. 565-578. Date of Electronic Publication: 2019 Apr 01. - Publication Year :
- 2019
-
Abstract
- Impact Statement: Due to high-fat and high-sugar diets accompanied by sedentary lifestyles, diabetes has become a global epidemic. Literature findings suggest a potential therapeutic effect of Nrg4 on treating obesity-related metabolic disorders including type 2 diabetes (T2D). Adipose tissue-derived MSCs (ADSCs) were used in our study as they are abundant and can be harvested with minimally invasive procedures. In the end, our study reveals that ADSC transplantation improves glucose tolerance and metabolic balance in HFD-fed mice by multiple mechanisms, including upregulating GLUT4 expression and suppressing inflammation. More importantly, our study shows that Nrg4 overexpression could improve the efficacy of ADSCs in ameliorating insulin resistance (IR) and other obesity-related metabolic disorders, given the function of Nrg4 in attenuating hepatic lipogenesis. It would provide a new therapeutic strategy for the treatment of obesity, IR, and T2D.
- Subjects :
- Adipose Tissue cytology
Adipose Tissue metabolism
Animals
Cells, Cultured
Cholesterol metabolism
Glucose Transporter Type 4 metabolism
Lipogenesis
Liver metabolism
Male
Mesenchymal Stem Cells cytology
Mice
Mice, Inbred C57BL
Neuregulins metabolism
Sterol Regulatory Element Binding Protein 1 metabolism
Triglycerides metabolism
Tumor Necrosis Factor-alpha metabolism
Fatty Liver therapy
Genetic Therapy methods
Insulin Resistance
Mesenchymal Stem Cell Transplantation methods
Mesenchymal Stem Cells metabolism
Neuregulins genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1535-3699
- Volume :
- 244
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Experimental biology and medicine (Maywood, N.J.)
- Publication Type :
- Academic Journal
- Accession number :
- 30935234
- Full Text :
- https://doi.org/10.1177/1535370219839643