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No impact of treated hyperprolactinemia on cumulative live birth rate and perinatal outcomes in in vitro fertilization-embryo transfer.
- Source :
-
The journal of obstetrics and gynaecology research [J Obstet Gynaecol Res] 2019 Jul; Vol. 45 (7), pp. 1236-1244. Date of Electronic Publication: 2019 Apr 01. - Publication Year :
- 2019
-
Abstract
- Aim: To investigate whether treated hyperprolactinemia has an impact on pregnancy outcomes in in vitro fertilization/intracytoplasmic sperm injection-embryo transfer (IVF/ICSI-ET).<br />Methods: A retrospective cohort study was conducted on 535 women who underwent IVF/ICSI-ET between January 2012 and December 2016, of which 123 had treated hyperprolactinemia (case group), 369 were matched controls. Besides, 43 remained hyperprolactinemic after treatment consisted of abnormal group. Cumulative live birth rate (CLBR) after one oocyte retrieval cycle was taken as the primary outcome. A time-to-event analysis using Fine and Gray's test was used to compare CLBR between case and control groups.<br />Results: The median prolactin level was 80.00 ng/mL before dopamine agonist treatment in case group, and it reduced to 14.80 ng/mL after the treatment, similar to the level of control group (15.17 ng/mL, P = 0.316). No significant differences in baseline characteristics were found between case and control groups. The CLBR after one oocyte retrieval cycle were 69.1% (85/123) and 66.4% (245/369) in the case group and control group, respectively (P = 0.580). No significant differences were found between case and control groups in perinatal outcomes. Pregnancy and perinatal outcomes of abnormal group were similar to those of case and control groups.<br />Conclusion: Impact of treated hyperprolactinemia on CLBR and perinatal outcomes in IVF-ET was not evident.<br /> (© 2019 Japan Society of Obstetrics and Gynecology.)
- Subjects :
- Adult
Birth Rate
Case-Control Studies
Dopamine Agonists therapeutic use
Female
Humans
Hyperprolactinemia drug therapy
Live Birth
Parturition
Pregnancy
Retrospective Studies
Time and Motion Studies
Treatment Outcome
Embryo Transfer statistics & numerical data
Fertilization in Vitro statistics & numerical data
Hyperprolactinemia physiopathology
Oocyte Retrieval statistics & numerical data
Sperm Injections, Intracytoplasmic statistics & numerical data
Subjects
Details
- Language :
- English
- ISSN :
- 1447-0756
- Volume :
- 45
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- The journal of obstetrics and gynaecology research
- Publication Type :
- Academic Journal
- Accession number :
- 30932283
- Full Text :
- https://doi.org/10.1111/jog.13957