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Genetic Architectures of Childhood- and Adult-Onset Asthma Are Partly Distinct.

Authors :: Ferreira MAR
Mathur R
Vonk JM
Szwajda A
Brumpton B
Granell R
Brew BK
Ullemar V
Lu Y
Jiang Y
Magnusson PKE
Karlsson R
Hinds DA
Paternoster L
Koppelman GH
Almqvist C
Source :: American journal of human genetics [Am J Hum Genet] 2019 Apr 04; Vol. 104 (4), pp. 665-684. Date of Electronic Publication: 2019 Mar 28.
Publication Year :: 2019
Abstract: The extent to which genetic risk factors are shared between childhood-onset (COA) and adult-onset (AOA) asthma has not been estimated. On the basis of data from the UK Biobank study (n = 447,628), we found that the variance in disease liability explained by common variants is higher for COA (onset at ages between 0 and 19 years; h <superscript>2</superscript> <subscript>g</subscript> = 25.6%) than for AOA (onset at ages between 20 and 60 years; h <superscript>2</superscript> <subscript>g</subscript> = 10.6%). The genetic correlation (r <subscript>g</subscript> ) between COA and AOA was 0.67. Variation in age of onset among COA-affected individuals had a low heritability (h <superscript>2</superscript> <subscript>g</subscript> = 5%), which we confirmed in independent studies and also among AOA-affected individuals. To identify subtype-specific genetic associations, we performed a genome-wide association study (GWAS) in the UK Biobank for COA (13,962 affected individuals) and a separate GWAS for AOA (26,582 affected individuals) by using a common set of 300,671 controls for both studies. We identified 123 independent associations for COA and 56 for AOA (37 overlapped); of these, 98 and 34, respectively, were reproducible in an independent study (n = 262,767). Collectively, 28 associations were not previously reported. For 96 COA-associated variants, including five variants that represent COA-specific risk factors, the risk allele was more common in COA- than in AOA-affected individuals. Conversely, we identified three variants that are stronger risk factors for AOA. Variants associated with obesity and smoking had a stronger contribution to the risk of AOA than to the risk of COA. Lastly, we identified 109 likely target genes of the associated variants, primarily on the basis of correlated expression quantitative trait loci (up to n = 31,684). GWAS informed by age of onset can identify subtype-specific risk variants, which can help us understand differences in pathophysiology between COA and AOA and so can be informative for drug development.<br /> (Copyright © 2019 American Society of Human Genetics. Published by Elsevier Inc. All rights reserved.)