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Molecular genetics and therapeutic targets of pediatric low-grade gliomas.
- Source :
-
Brain tumor pathology [Brain Tumor Pathol] 2019 Apr; Vol. 36 (2), pp. 74-83. Date of Electronic Publication: 2019 Mar 30. - Publication Year :
- 2019
-
Abstract
- Pediatric low-grade gliomas (PLGGs) have relatively favorable prognosis and some resectable PLGGs, such as cerebellar pilocytic astrocytoma, can be cured by surgery alone. However, many PLGG cases are unresectable and some of them undergo tumor progression. Therefore, a multidisciplinary approach is necessary to treat PLGG patients. Recent genomic analysis revealed a broad genomic landscape underlying PLGG. Notably, the majority of PLGGs present MAPK pathway-associated genomic alterations and MAPK signaling-dependent tumor progression. Following preclinical evidence, many clinical trials based on molecular target therapy have been conducted on PLGG patients, some of whom exhibited durable response to target therapy. Here, we provide an overview of PLGG genetics and the evidence supporting the application of molecular target therapy in these patients.
- Subjects :
- Adolescent
Astrocytoma genetics
Astrocytoma pathology
Astrocytoma therapy
Brain Neoplasms genetics
Brain Neoplasms pathology
Brain Neoplasms therapy
Child
Child, Preschool
Glioma therapy
Humans
Infant
Mitogen-Activated Protein Kinases metabolism
Mutation genetics
Oncogene Proteins, Fusion genetics
Oncogene Proteins, Fusion metabolism
Proto-Oncogene Proteins B-raf
Glioma genetics
Glioma pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1861-387X
- Volume :
- 36
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Brain tumor pathology
- Publication Type :
- Academic Journal
- Accession number :
- 30929113
- Full Text :
- https://doi.org/10.1007/s10014-019-00340-3