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Neuroepigenetics of arousal: Gamma oscillations in the pedunculopontine nucleus.
- Source :
-
Journal of neuroscience research [J Neurosci Res] 2019 Dec; Vol. 97 (12), pp. 1515-1520. Date of Electronic Publication: 2019 Mar 27. - Publication Year :
- 2019
-
Abstract
- Four major discoveries on the function of the pedunculopontine nucleus (PPN) have significantly advanced our understanding of the role of arousal in neurodegenerative disorders. The first was the finding that stimulation of the PPN-induced controlled locomotion on a treadmill in decerebrate animals, the second was the revelation of electrical coupling in the PPN and other arousal and sleep-wake control regions, the third was the determination of intrinsic gamma band oscillations in PPN neurons, and the last was the discovery of gene transcription resulting from the manifestation of gamma activity in the PPN. These discoveries have led to novel therapies such as PPN deep brain stimulation (DBS) for Parkinson's disease (PD), identified the mechanism of action of the stimulant modafinil, determined the presence of separate mechanisms underlying gamma activity during waking versus REM sleep, and revealed the presence of gene transcription during the manifestation of gamma band oscillations. These discoveries set the stage for additional major advances in the treatment of a number of disorders.<br /> (© 2019 Wiley Periodicals, Inc.)
- Subjects :
- Acetylation
Animals
Calcium Channels physiology
Central Nervous System Stimulants therapeutic use
Decerebrate State
Deep Brain Stimulation
GABAergic Neurons physiology
Gait physiology
Gene Expression Regulation
Histones metabolism
Humans
Modafinil therapeutic use
Neurodegenerative Diseases physiopathology
Parkinson Disease physiopathology
Pedunculopontine Tegmental Nucleus physiopathology
Protein Processing, Post-Translational
Sleep, REM physiology
Transcription, Genetic
Wakefulness physiology
Arousal physiology
Gamma Rhythm physiology
Pedunculopontine Tegmental Nucleus physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1097-4547
- Volume :
- 97
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Journal of neuroscience research
- Publication Type :
- Academic Journal
- Accession number :
- 30916810
- Full Text :
- https://doi.org/10.1002/jnr.24417