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Drug resistance profile of Mycobacterium tuberculosis and predictors associated with the development of drug resistance.
- Source :
-
Journal of global antimicrobial resistance [J Glob Antimicrob Resist] 2019 Sep; Vol. 18, pp. 155-159. Date of Electronic Publication: 2019 Mar 22. - Publication Year :
- 2019
-
Abstract
- Objectives: Drug-resistant tuberculosis (DR-TB) is a major challenge to national TB control programmes in developing countries. In the Pakistan province of Punjab, the extent and development of DR-TB is not well known. The current study was therefore conducted to assess the incidence and predictors of DR-TB in Punjab Province.<br />Methods: Drug susceptibility testing was performed for 863 confirmed culture-positive Mycobacterium tuberculosis isolates using the proportion method. Patients were enrolled in the Programmatic Management of Drug-Resistant TB Unit of Gulab Devi Chest Hospital (Lahore, Pakistan) from August 2011 to September 2013. Data analysis was performed using IBS SPSS Statistics v.20. Multivariate logistic regression analysis was performed to assess risk factors for DR-TB.<br />Results: The rate of resistance to at least one drug (i.e. DR-TB) was 35.0% (302/863) and the rate of multidrug-resistant TB (MDR-TB) was 30.0% (259/863). Among DR-TB cases, the number of females was relatively higher (167/302; 55.3%) compared with males. The majority of DR-TB patients resided in a rural area (229/302; 75.8%). Significant predictors of DR-TB were age 18-45 years, previous TB treatment, rural residence, being a housewife, being married, duration of sickness >1year and unemployment.<br />Conclusion: The problem of DR-TB in Pakistan is significant. The strongest risk factors were young age and previous anti-TB treatment. Being married, being a housewife, rural residence and unemployment were also risk factors, culminating in an urgent need for effective control, early diagnosis and treatment policies for DR-TB.<br /> (Copyright © 2019 International Society for Antimicrobial Chemotherapy. Published by Elsevier Ltd. All rights reserved.)
- Subjects :
- Adolescent
Adult
Aged
Aged, 80 and over
Child
Female
Humans
Logistic Models
Male
Microbial Sensitivity Tests
Middle Aged
Multivariate Analysis
Mycobacterium tuberculosis isolation & purification
Pakistan epidemiology
Regression Analysis
Risk Factors
Tuberculosis, Multidrug-Resistant drug therapy
Young Adult
Antitubercular Agents pharmacology
Drug Resistance, Multiple, Bacterial drug effects
Mycobacterium tuberculosis drug effects
Tuberculosis, Multidrug-Resistant epidemiology
Tuberculosis, Multidrug-Resistant microbiology
Subjects
Details
- Language :
- English
- ISSN :
- 2213-7173
- Volume :
- 18
- Database :
- MEDLINE
- Journal :
- Journal of global antimicrobial resistance
- Publication Type :
- Academic Journal
- Accession number :
- 30910744
- Full Text :
- https://doi.org/10.1016/j.jgar.2019.03.009