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Reduction of Left Ventricular Dilation Beyond the First Year After Anterior Myocardial Infarction.
- Source :
-
Journal of cardiac failure [J Card Fail] 2019 Aug; Vol. 25 (8), pp. 645-653. Date of Electronic Publication: 2019 Mar 22. - Publication Year :
- 2019
-
Abstract
- Background: Reduction of left ventricular (LV) dilation (RD) beyond the first year after ST-segment-elevation myocardial infarction (STEMI) is unknown. We investigated its potential occurrence in comparison with stationary (SD) and progressive (PD) dilation.<br />Methods and Results: Perfusion gated SPECT features at 1 and 3 years were evaluated in 168 3-year survivors of a first anterior STEMI. Comparisons were made among patients with RD (≥15% reduction of LV end-systolic volume [LVESV]), SD (<15% reduction or increase), and PD (≥15% increase). There were 35 patients with RD (21%), 84 with SD (50%), and 49 with PD (29%). At 1 year, ejection fraction, wall motion and perfusion scores, and LV volumes were similar. In RD patients, the fall in LVESV, nearly 22%, was apparent in those with frank (>51 mL; P < .001) or little/moderate LV dilation at 1 year (LVESV ≤51 mL; P = .002) and was associated with increased ejection fraction (P values .008 and .009, respectively). In the 3 groups, however, LVESV changes were unrelated to 1-year LV volumes, ejection fraction, or contractility score.<br />Conclusions: At 3 years following anterior STEMI there is reduction of LV dilation in about 21% of patients associated with increases in ejection fraction in those with or without clearly dilated ventricles at 1year. These findings add to the complexity of LV remodeling and possibly suggest very late changes in infarct size.<br /> (Copyright © 2019 Elsevier Inc. All rights reserved.)
- Subjects :
- Aged
Echocardiography methods
Electrocardiography methods
Female
Follow-Up Studies
Humans
Male
Middle Aged
ST Elevation Myocardial Infarction metabolism
Time Factors
Tomography, Emission-Computed, Single-Photon methods
ST Elevation Myocardial Infarction diagnostic imaging
ST Elevation Myocardial Infarction physiopathology
Ventricular Remodeling physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1532-8414
- Volume :
- 25
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Journal of cardiac failure
- Publication Type :
- Academic Journal
- Accession number :
- 30910449
- Full Text :
- https://doi.org/10.1016/j.cardfail.2019.03.012