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[Analyses of clinical and radiological characteristics of IgG4-related rhinosinusitis].
- Source :
-
Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery [Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi] 2019 Mar 07; Vol. 54 (3), pp. 187-191. - Publication Year :
- 2019
-
Abstract
- Objectives: To discuss the clinical and radiological features of IgG4-related rhinosinusitis. Methods: In this retrospective research, the clinical data of 16 patients diagnosed with IgG4 related rhinosinusitis, who were enrolled in Beijing Tongren Hospital from November 2013 to September 2017, were collected. The clinical features, laboratory findings, radiological findings, histological features, treatment and prognosis were all summarized. Results: There were 12 males and 4 females among 16 patients, and male-to-female ratio was 3︰1. The age was between 30 to 70 years old, with median age of 52 years old. The chief nasal complaints were nasal obstruction and hyposmia, complicated with proptosis and eyelid swelling in 11 patients (11/16). Serum IgG4 levels were elevated in all patients and the value was over 1.44 g/L, and one patient serum IgG4 level was up to 49.70 g/L. Computed tomography (CT) showed the mainly affected sinuses were bilateral ethmoid sinus and olfactory cleft. The classic feature of CT scans was thickening of the involved bilateral ethmoid sinus mucous membrane with ethmoid bone absorption, which was mainly at midline. Histological features were severe inflammation of the mucosal tissue with mass of neutrophils and plasma cell infiltration. All patients were treated by methylprednisolone combined with cyclophosphamide or methotrexate. Remission of symptoms was detected in all patients. Conclusion: The clinical features of IgG4-related rhinosinusitis are often accompanied by orbital tissue involvement, elevated IgG4 serum concentration, associated sinus imaging changes, and sensitive glucocorticoid and immunosuppressive therapy.
- Subjects :
- Adult
Aged
Blepharitis etiology
Exophthalmos etiology
Female
Humans
Immunoglobulin G blood
Immunoglobulin G4-Related Disease blood
Immunoglobulin G4-Related Disease drug therapy
Male
Middle Aged
Nasal Obstruction etiology
Olfaction Disorders etiology
Paranasal Sinuses
Retrospective Studies
Rhinitis blood
Rhinitis drug therapy
Sinusitis blood
Sinusitis drug therapy
Tomography, X-Ray Computed
Immunoglobulin G4-Related Disease complications
Rhinitis complications
Sinusitis complications
Subjects
Details
- Language :
- Chinese
- ISSN :
- 1673-0860
- Volume :
- 54
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery
- Publication Type :
- Academic Journal
- Accession number :
- 30909338
- Full Text :
- https://doi.org/10.3760/cma.j.issn.1673-0860.2019.03.005