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Metabolomics of neonatal blood spots reveal distinct phenotypes of pediatric acute lymphoblastic leukemia and potential effects of early-life nutrition.
- Source :
-
Cancer letters [Cancer Lett] 2019 Jun 28; Vol. 452, pp. 71-78. Date of Electronic Publication: 2019 Mar 20. - Publication Year :
- 2019
-
Abstract
- Early-life exposures are believed to influence the incidence of pediatric acute lymphoblastic leukemia (ALL). Archived neonatal blood spots (NBS), collected within the first days of life, offer a means to investigate small molecules that reflect early-life exposures. Using untargeted metabolomics, we compared abundances of small-molecule features in extracts of NBS punches from 332 children that later developed ALL and 324 healthy controls. Subjects were stratified by early (1-5 y) and late (6-14 y) diagnosis. Mutually-exclusive sets of metabolic features - representing putative lipids and fatty acids - were associated with ALL, including 9 and 19 metabolites in the early- and late-diagnosis groups, respectively. In the late-diagnosis group, a prominent cluster of features with apparent 18:2 fatty-acid chains suggested that newborn exposure to the essential nutrient, linoleic acid, increased ALL risk. Interestingly, abundances of these putative 18:2 lipids were greater in infants who were fed formula rather than breast milk (colostrum) and increased with the mother's pre-pregnancy body mass index. These results suggest possible etiologic roles of newborn nutrition in late-diagnosis ALL.<br /> (Copyright © 2019 Elsevier B.V. All rights reserved.)
- Subjects :
- Adolescent
Age Factors
Biomarkers blood
Bottle Feeding
Breast Feeding
California epidemiology
Child
Child, Preschool
Female
Humans
Incidence
Infant
Infant Formula
Infant, Newborn
Male
Precursor Cell Lymphoblastic Leukemia-Lymphoma blood
Precursor Cell Lymphoblastic Leukemia-Lymphoma diagnosis
Precursor Cell Lymphoblastic Leukemia-Lymphoma prevention & control
Protective Factors
Risk Assessment
Risk Factors
Dried Blood Spot Testing
Energy Metabolism
Infant Nutritional Physiological Phenomena
Lipids blood
Metabolomics
Neonatal Screening methods
Nutritional Status
Precursor Cell Lymphoblastic Leukemia-Lymphoma epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1872-7980
- Volume :
- 452
- Database :
- MEDLINE
- Journal :
- Cancer letters
- Publication Type :
- Academic Journal
- Accession number :
- 30904619
- Full Text :
- https://doi.org/10.1016/j.canlet.2019.03.007