Back to Search
Start Over
Obesity risk and preference for high dietary fat intake are determined by FTO rs9939609 gene polymorphism in selected Indonesian adults.
- Source :
-
Asia Pacific journal of clinical nutrition [Asia Pac J Clin Nutr] 2019; Vol. 28 (1), pp. 183-191. - Publication Year :
- 2019
-
Abstract
- Background and Objectives: Data suggest that genetic factors are associated with BMI. The fat mass and obesity- associated (FTO) gene modulates adipogenesis through alternative splicing and m6A demethylation. Individuals with FTO rs9939609 gene polymorphism have a preference for energy-dense foods. This study investigates the relationship between FTO rs9939609 and obesity and preference for dietary fat intake among selected Indonesian adults.<br />Methods and Study Design: A total of 40 non-obese and 40 obese participants aged 19-59 living in Jakarta were recruited. Body composition measurements included body weight, height, BMI, waist circumference, and body fat mass. Dietary intake was assessed using a semiquantitative food frequency questionnaire and food recall over 2 × 24-h periods. Genetic variation was determined using amplification-refractory mutation system polymerase chain reaction.<br />Results: The genotype distribution of the FTO gene (rs9939609) was at Hardy- Weinberg equilibrium (p=1) with minor allele frequency=0.19. Individuals with AT/AA genotypes had 3.72 times higher risk of obesity (p=0.009) and 5.98 times higher dietary fat intake (p=0.02) than those with TT genotype. Obese participants with the AT/AA genotypes had 1.40 times higher dietary fat intake than those with the TT genotype (p=0.016).<br />Conclusions: These findings suggest that Indonesian adults with AT/AA genotypes of the FTO rs9939609 have higher obesity risks and preferences for high dietary fat intake than those with TT genotype.
- Subjects :
- Adult
Case-Control Studies
Female
Genotype
Humans
Indonesia epidemiology
Male
Middle Aged
Obesity chemically induced
Obesity epidemiology
Young Adult
Alpha-Ketoglutarate-Dependent Dioxygenase FTO genetics
Diet, High-Fat adverse effects
Genetic Predisposition to Disease
Obesity genetics
Polymorphism, Genetic
Polymorphism, Single Nucleotide
Subjects
Details
- Language :
- English
- ISSN :
- 1440-6047
- Volume :
- 28
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Asia Pacific journal of clinical nutrition
- Publication Type :
- Academic Journal
- Accession number :
- 30896430
- Full Text :
- https://doi.org/10.6133/apjcn.201903_28(1).0024