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Effect of a radiographic contrast agent on renal function in the rat. Comparison with equiosmolar mannitol.
- Source :
-
Mineral and electrolyte metabolism [Miner Electrolyte Metab] 1986; Vol. 12 (3), pp. 157-60. - Publication Year :
- 1986
-
Abstract
- The renal effects of the radiographic contrast agent meglumine iothalamate (Conray; C) were evaluated in rats. C produced a 42% fall in glomerular filtration rate (p less than 0.05) and a 44% fall in effective renal plasma flow (p less than 0.05). The effects of C were blunted by both acute and chronic volume expansion. Equiosmolar mannitol produced similar hemodynamic responses as C. The fractional excretions of sodium and potassium were similar in rats given C or mannitol. The renal effects of C appear to be due to its hypertonicity. These effects may be modified by volume expansion.
- Subjects :
- Animals
Evaluation Studies as Topic
Infusions, Intra-Arterial
Iothalamate Meglumine administration & dosage
Kidney drug effects
Kidney Glomerulus metabolism
Mannitol administration & dosage
Rats
Rats, Inbred Strains
Sodium urine
Contrast Media pharmacology
Iothalamate Meglumine pharmacology
Kidney physiology
Mannitol pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0378-0392
- Volume :
- 12
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Mineral and electrolyte metabolism
- Publication Type :
- Academic Journal
- Accession number :
- 3088415