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Switching from ranibizumab to aflibercept in choroidal neovascularization secondary to angioid streaks.
- Source :
-
European journal of ophthalmology [Eur J Ophthalmol] 2020 May; Vol. 30 (3), pp. 550-556. Date of Electronic Publication: 2019 Mar 18. - Publication Year :
- 2020
-
Abstract
- Purpose: To evaluate the efficacy of switching from intravitreal ranibizumab to intravitreal aflibercept in choroidal neovascularization secondary to angioid streaks.<br />Design: Multicenter retrospective interventional case series.<br />Methods: Patients previously treated with intravitreal ranibizumab with at least 12-month follow-up (M12) after switching (M0) to intravitreal aflibercept. Switch to intravitreal aflibercept was decided in cases of refractory or recurrent choroidal neovascularization. Primary endpoint: Change of best-corrected visual acuity using the Early Treatment Diabetic Retinopathy Study letters. Secondary endpoints: Mean change of central macular thickness, absence of intraretinal/subretinal fluid on spectral domain optical coherence tomography and the percentage of eyes with absence of leakage on fluorescein angiography.<br />Results: Fourteen eyes of 13 patients were included. Mean best-corrected visual acuity was 65.0 ± 21.03 letters at M0 and 63.5 ± 17.30 letters at M12 (p = 0.5). Secondary endpoints: Mean central macular thickness was 344 ± 194.65 µm at M0 and 268 ± 79.97 µm at M12 (p = 0.008). Absence of intraretinal/subretinal fluid was observed in 71%. Fluorescein angiography (nine eyes) showed absence of leakage in 77% (seven eyes).<br />Conclusion: Switching from intravitreal ranibizumab to intravitreal aflibercept represents a therapeutic option in patients with refractory or recurrent choroidal neovascularization secondary to angioid streaks.
- Subjects :
- Aged
Aged, 80 and over
Angioid Streaks physiopathology
Choroidal Neovascularization etiology
Choroidal Neovascularization physiopathology
Drug Substitution
Female
Fluorescein Angiography
Follow-Up Studies
Humans
Intravitreal Injections
Male
Middle Aged
Retrospective Studies
Tomography, Optical Coherence methods
Treatment Outcome
Vascular Endothelial Growth Factor A antagonists & inhibitors
Visual Acuity physiology
Angiogenesis Inhibitors therapeutic use
Angioid Streaks complications
Choroidal Neovascularization drug therapy
Ranibizumab therapeutic use
Receptors, Vascular Endothelial Growth Factor therapeutic use
Recombinant Fusion Proteins therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1724-6016
- Volume :
- 30
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- European journal of ophthalmology
- Publication Type :
- Academic Journal
- Accession number :
- 30880436
- Full Text :
- https://doi.org/10.1177/1120672119838133