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Effective connectivity analysis of iEEG and accurate localization of the epileptogenic focus at the onset of operculo-insular seizures.
- Source :
-
Epilepsy research [Epilepsy Res] 2019 May; Vol. 152, pp. 42-51. Date of Electronic Publication: 2019 Mar 11. - Publication Year :
- 2019
-
Abstract
- Recognition of insular epilepsy may sometimes be challenging due to the rapid speed at which insular seizures can spread throughout the cortex via extensive connections to surrounding cortices. The spectrum weighted adaptive directed transfer function, a multivariate causality-based effective connectivity measure, was applied to intracranial electroencephalography recordings to identify generators of seizure activity. A non-parametric test based on surrogate data testing was used to validate statistical significance of causal relations. Outflow and inflow of seizure activity were extracted from the computed transfer matrix. Recorded data of 21 seizures from seven patients were analyzed including five who were rendered seizure-free after operculo-insular resection. Effective connectivity analysis of 7 s following electrical onset confirmed an operculo-insular seizure origin in 5 patients with a good post-operative seizure outcome, and for whom the resected region was sampled by intracranial electroencephalography contacts. Different or additional seizure foci were identified in 2 patients with a bad post-operative seizure outcome. Findings highlight the feasibility of accurate operculo-insular seizure foci localization based on quantitative approaches.<br /> (Copyright © 2019 Elsevier B.V. All rights reserved.)
- Subjects :
- Adolescent
Adult
Computer Simulation
Epilepsy, Frontal Lobe diagnostic imaging
Epilepsy, Frontal Lobe surgery
Female
Humans
Magnetic Resonance Imaging
Magnetoencephalography
Male
Middle Aged
Models, Neurological
Spectrum Analysis
Temporal Lobe surgery
Time Factors
Tomography, Emission-Computed, Single-Photon
Brain Mapping
Electrocorticography
Epilepsy, Frontal Lobe pathology
Epilepsy, Frontal Lobe physiopathology
Temporal Lobe physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 1872-6844
- Volume :
- 152
- Database :
- MEDLINE
- Journal :
- Epilepsy research
- Publication Type :
- Academic Journal
- Accession number :
- 30878795
- Full Text :
- https://doi.org/10.1016/j.eplepsyres.2019.02.006