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MRI Imaging of the Hemodynamic Vasculature of Neuroblastoma Predicts Response to Antiangiogenic Treatment.
- Source :
-
Cancer research [Cancer Res] 2019 Jun 01; Vol. 79 (11), pp. 2978-2991. Date of Electronic Publication: 2019 Mar 15. - Publication Year :
- 2019
-
Abstract
- Childhood neuroblastoma is a hypervascular tumor of neural origin, for which antiangiogenic drugs are currently being evaluated; however, predictive biomarkers of treatment response, crucial for successful delivery of precision therapeutics, are lacking. We describe an MRI-pathologic cross-correlative approach using intrinsic susceptibility (IS) and susceptibility contrast (SC) MRI to noninvasively map the vascular phenotype in neuroblastoma Th-MYCN transgenic mice treated with the vascular endothelial growth factor receptor inhibitor cediranib. We showed that the transverse MRI relaxation rate R <subscript>2</subscript> * (second <superscript>-1</superscript> ) and fractional blood volume ( f BV, %) were sensitive imaging biomarkers of hemorrhage and vascular density, respectively, and were also predictive biomarkers of response to cediranib. Comparison with MRI and pathology from patients with MYCN-amplified neuroblastoma confirmed the high degree to which the Th-MYCN model vascular phenotype recapitulated that of the clinical phenotype, thereby supporting further evaluation of IS- and SC-MRI in the clinic. This study reinforces the potential role of functional MRI in delivering precision medicine to children with neuroblastoma. SIGNIFICANCE: This study shows that functional MRI predicts response to vascular-targeted therapy in a genetically engineered murine model of neuroblastoma.<br /> (©2019 American Association for Cancer Research.)
- Subjects :
- Animals
Child
Child, Preschool
Contrast Media
Female
Humans
Infant
Male
Mice, Transgenic
N-Myc Proto-Oncogene Protein genetics
Neoplasms, Experimental
Neuroblastoma blood supply
Prospective Studies
Protein Kinase Inhibitors pharmacology
Treatment Outcome
Angiogenesis Inhibitors pharmacology
Magnetic Resonance Imaging methods
Neuroblastoma diagnostic imaging
Neuroblastoma drug therapy
Quinazolines pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1538-7445
- Volume :
- 79
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Cancer research
- Publication Type :
- Academic Journal
- Accession number :
- 30877107
- Full Text :
- https://doi.org/10.1158/0008-5472.CAN-18-3412