Back to Search
Start Over
Immobilization of nano Cu-MOFs with polydopamine coating for adaptable gasotransmitter generation and copper ion delivery on cardiovascular stents.
- Source :
-
Biomaterials [Biomaterials] 2019 Jun; Vol. 204, pp. 36-45. Date of Electronic Publication: 2019 Mar 09. - Publication Year :
- 2019
-
Abstract
- In-stent restenosis is worsened by thrombosis, acute inflammation, and uncontrollable smooth muscle cells (SMCs) proliferation at the early stage of implantation. Tailoring the stent surface can inhibit thrombosis, intimal hyperplasia, and accelerate re-endothelialization. In situ nitric oxide (NO) generation is considered as a promising method to improve anti-coagulation and anti-hyperplasia abilities. Copper based metal organic frameworks showed great potential as catalysts for NO generation, and copper ion (Cu <superscript>2+</superscript> ) was demonstrated to promote endothelial cells (ECs) growth. Herein, by using polydopamine as the linker and coating matrix, nanoscale copper-based metal organic frameworks (nano Cu-MOFs) were immobilized onto the titanium surface for simultaneous nitric oxide (NO) catalytic generation and Cu <superscript>2+</superscript> delivery. The nano Cu-MOFs-immobilized coating exhibited desirable NO release and adaptable Cu <superscript>2+</superscript> delivery. Such coating inhibited platelet aggregation and activation via NO-cGMP signaling pathway, and significantly reduced thrombosis in an ex vivo extracorporeal circulation model. NO release and Cu <superscript>2+</superscript> delivery showed synergetic effect to promote EC proliferation. Moreover, SMCs and macrophage proliferation was suppressed by the nano Cu-MOFs-immobilized coating, thereby reducing neointimal hyperplasia in vivo. Overall, this biocompatible coating is convenient for the surface modification of cardiovascular stents and effectively prevents the late stent thrombosis and in-stent restenosis associated with stent implantation.<br /> (Copyright © 2019. Published by Elsevier Ltd.)
- Subjects :
- Animals
Cell Proliferation
Cyclic GMP metabolism
Endothelial Cells cytology
Humans
Implants, Experimental
Male
Metal-Organic Frameworks ultrastructure
Mice
Myocytes, Smooth Muscle cytology
Nanoparticles ultrastructure
Nitric Oxide metabolism
Platelet Activation
Platelet Adhesiveness
RAW 264.7 Cells
Rabbits
Rats, Sprague-Dawley
Cardiovascular System pathology
Coated Materials, Biocompatible chemistry
Copper chemistry
Gasotransmitters analysis
Indoles chemistry
Metal-Organic Frameworks chemistry
Nanoparticles chemistry
Polymers chemistry
Stents
Subjects
Details
- Language :
- English
- ISSN :
- 1878-5905
- Volume :
- 204
- Database :
- MEDLINE
- Journal :
- Biomaterials
- Publication Type :
- Academic Journal
- Accession number :
- 30875517
- Full Text :
- https://doi.org/10.1016/j.biomaterials.2019.03.007