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PD-L1 expression combined with microsatellite instability/CD8+ tumor infiltrating lymphocytes as a useful prognostic biomarker in gastric cancer.
- Source :
-
Scientific reports [Sci Rep] 2019 Mar 15; Vol. 9 (1), pp. 4633. Date of Electronic Publication: 2019 Mar 15. - Publication Year :
- 2019
-
Abstract
- While the importance of programmed death-ligand 1 (PD-L1), mutation burden caused by microsatellite instability (MSI), and CD8+ tumor infiltrating lymphocytes (TILs) has become evident, the significance of PD-L1 expression on prognosis still remains controversial. We evaluated the usefulness of combined markers of PD-L1 and MSI or CD8+ TILs as a prognostic biomarker in gastric cancer. A total of 283 patients with gastric cancer were reviewed retrospectively. PD-L1 expression on >5% tumor cells was defined as PD-L1-positive. PD-L1-positive rate was 15.5% (44/283). PD-L1 positivity was significantly correlated with invasive and advanced cancer and also significantly correlated with MSI, whereas no significance was observed with CD8+ TILs. Kaplan-Meier analysis showed that PD-L1 positivity significantly correlated with a poor prognosis (pā=ā0.0025). Multivariate analysis revealed that PD-L1 positivity was an independent poor prognostic factor (hazard ratio [HR]: 1.97, pā=ā0.0106) along with diffuse histological type and lymph node metastases. Combinations of PD-L1 and MSI (HR: 2.18) or CD8+ TILs (HR: 2.57) were stronger predictive factors for prognosis than PD-L1 alone. In conclusion, combined markers of PD-L1 and MSI or CD8+ TILs may be more useful prognostic biomarkers in gastric cancer, and better clarify the immune status of gastric cancer patients.
- Subjects :
- Adult
Aged
Aged, 80 and over
B7-H1 Antigen metabolism
Biomarkers, Tumor blood
Disease-Free Survival
Female
Humans
Kaplan-Meier Estimate
Lymphatic Metastasis pathology
Lymphocytes, Tumor-Infiltrating immunology
Male
Microsatellite Instability
Microsatellite Repeats genetics
Middle Aged
Prognosis
Proportional Hazards Models
Retrospective Studies
Stomach Neoplasms immunology
B7-H1 Antigen genetics
CD8-Positive T-Lymphocytes immunology
Stomach Neoplasms genetics
Subjects
Details
- Language :
- English
- ISSN :
- 2045-2322
- Volume :
- 9
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Scientific reports
- Publication Type :
- Academic Journal
- Accession number :
- 30874607
- Full Text :
- https://doi.org/10.1038/s41598-019-41177-2