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Circulating CD56 bright NK cells inversely correlate with survival of melanoma patients.
- Source :
-
Scientific reports [Sci Rep] 2019 Mar 14; Vol. 9 (1), pp. 4487. Date of Electronic Publication: 2019 Mar 14. - Publication Year :
- 2019
-
Abstract
- The roles of NK cells in human melanoma remain only partially understood. We characterized NK cells from peripheral blood ex vivo by flow cytometry obtained from late stage (III/IV) melanoma patients. Interestingly, we found that the abundance of CD56 <superscript>bright</superscript> NK cells negatively correlate with overall patient survival, together with distant metastases, in a multivariate cox regression analysis. The patients' CD56 <superscript>bright</superscript> NK cells showed upregulation of CD11a, CD38 and CD95 as compared to healthy controls, pointing to an activated phenotype as well as a possible immune regulatory role in melanoma patients. After stimulation in vitro, CD56 <superscript>bright</superscript> NK cells produced less TNFα and GMCSF in patients than controls. Furthermore, IFNγ production by the CD56 <superscript>bright</superscript> NK cells correlated inversely with overall survival. Our results highlight that abundance and function of CD56 <superscript>bright</superscript> NK cells are associated with melanoma patient survival, emphasizing the potential of NK cell subsets for biomarker discovery and future therapeutic targeting.
- Subjects :
- Case-Control Studies
Female
Flow Cytometry
Granulocyte-Macrophage Colony-Stimulating Factor metabolism
Humans
Interferon-gamma metabolism
Male
Melanoma immunology
Melanoma pathology
Neoplasm Metastasis
Neoplasm Staging
Phenotype
Regression Analysis
Survival Analysis
Biomarkers, Tumor blood
CD56 Antigen blood
Killer Cells, Natural immunology
Melanoma mortality
Subjects
Details
- Language :
- English
- ISSN :
- 2045-2322
- Volume :
- 9
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Scientific reports
- Publication Type :
- Academic Journal
- Accession number :
- 30872676
- Full Text :
- https://doi.org/10.1038/s41598-019-40933-8