Photodynamic activity and DNA binding studies of Pd@SiO 2 core-shell nanoparticles in vitro.

Authors :: Dhanalekshmi KI
Sangeetha K
Meena KS
Magesan P
Manikandan A
Jayamoorthy K
Source :: Photodiagnosis and photodynamic therapy [Photodiagnosis Photodyn Ther] 2019 Jun; Vol. 26, pp. 79-84. Date of Electronic Publication: 2019 Mar 09.
Publication Year :: 2019
Abstract: Metal-semiconductor core-shell type Pd@SiO <subscript>2</subscript> nanoparticles (NPs) were successfully synthesized by Stober's method and the product was characterized by UV-vis, XRD, FT-IR, SEM, HR-TEM and EDX techniques. In vitro Photodynamic activity and DNA binding studies of Pd@SiO <subscript>2</subscript> core shell nanoparticles were studied. Cell viability of the core-shell nanoparticles against HeLa cell line was screened by MTT assay after exposing at different light doses. The outcome of the present study indicates that the core-shell Pd@SiO <subscript>2</subscript> NPs are highly stable and exhibited strong photodynamic efficiency under LED light illumination in HeLa cells. The results indicated that SiO <subscript>2</subscript> supported on the surface of Pd NPs not only prevented the aggregation in addition exhibited remarkable photodynamic activity.<br /> (Copyright © 2019 Elsevier B.V. All rights reserved.)

Subjects :: Cell Survival
DNA chemistry
Humans
In Vitro Techniques
Surface Properties
DNA metabolism
HeLa Cells drug effects
Metal Nanoparticles chemistry
Photochemotherapy methods
Photosensitizing Agents chemistry
Photosensitizing Agents pharmacology
Protein Binding drug effects

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