Back to Search
Start Over
Tumor selective uptake of drug-nanodiamond complexes improves therapeutic outcome in pancreatic cancer.
- Source :
-
Nanomedicine : nanotechnology, biology, and medicine [Nanomedicine] 2019 Jun; Vol. 18, pp. 112-121. Date of Electronic Publication: 2019 Mar 06. - Publication Year :
- 2019
-
Abstract
- Pancreatic ductal adenocarcinoma (PDAC) is one of the leading causes of cancer-related deaths and novel treatment approaches are urgently needed. Here we show that poly(ethylene glycol)-functionalized nanodiamonds loaded with doxorubicin (ND-PEG-DOX) afforded a considerable improvement over free drug in an orthotopic pancreatic xenograft model. ND-PEG-DOX complexes were also superior to free DOX in 3-dimensional (3D) tumor spheroids of PDAC. ND-PEG showed no cytotoxicity towards macrophages, and histopathological analysis showed no abnormalities of major organs upon in vivo administration of ND-PEG-DOX. These results provide evidence that ND-mediated drug delivery may serve as a means of improving the therapeutic outcome in PDAC.<br /> (Copyright © 2019 The Author(s). Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Animals
Apoptosis drug effects
Cell Line, Tumor
Doxorubicin pharmacology
Doxorubicin therapeutic use
Drug Liberation
Endocytosis drug effects
Humans
Hydrodynamics
Male
Mice
Nanodiamonds ultrastructure
Pancreatic Neoplasms ultrastructure
Particle Size
Polyethylene Glycols chemistry
Spheroids, Cellular drug effects
Spheroids, Cellular pathology
Tissue Distribution drug effects
Treatment Outcome
Nanodiamonds chemistry
Pancreatic Neoplasms drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1549-9642
- Volume :
- 18
- Database :
- MEDLINE
- Journal :
- Nanomedicine : nanotechnology, biology, and medicine
- Publication Type :
- Academic Journal
- Accession number :
- 30849547
- Full Text :
- https://doi.org/10.1016/j.nano.2019.02.020