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Is there a reliable size cut-off for splenic involvement in lymphoma? A [18F]FDG-PET controlled study.
- Source :
-
PloS one [PLoS One] 2019 Mar 08; Vol. 14 (3), pp. e0213551. Date of Electronic Publication: 2019 Mar 08 (Print Publication: 2019). - Publication Year :
- 2019
-
Abstract
- Purpose: Aim of present study was to determine whether the currently recommended 13-cm cranio-caudal diameter cut-off on CT for assessment of splenic involvement in lymphoma offers adequate sensitivity and specificity.<br />Materials and Methods: Patients with histologically proven lymphoma who had undergone [18F]FDG-PET/CT before therapy were included. Cranio-caudal diameters of the spleen were measured on the CT component of PET/CT, and ROC analyses with calculation of respective areas under the curve (AUC) were used to determine cut-off values of cranio-caudal measurements with their respective sensitivities and specificities, using [18F]FDG-PET as the reference standard.<br />Results: In 93 patients, we found a sensitivity of 74.1% and a specificity of 47% for the 13-cm splenic diameter cut-off.<br />Conclusions: Our results show reasonable, though far from perfect sensitivities and specificities for the currently recommend 13-cm splenic diameter cut-off.<br />Competing Interests: The authors have declared that no competing interests exist.
Details
- Language :
- English
- ISSN :
- 1932-6203
- Volume :
- 14
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- PloS one
- Publication Type :
- Academic Journal
- Accession number :
- 30849131
- Full Text :
- https://doi.org/10.1371/journal.pone.0213551