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von Willebrand Factor and Management of Heart Valve Disease: JACC Review Topic of the Week.

Authors :
Van Belle E
Vincent F
Rauch A
Casari C
Jeanpierre E
Loobuyck V
Rosa M
Delhaye C
Spillemaeker H
Paris C
Debry N
Verdier B
Vincentelli A
Dupont A
Lenting PJ
Susen S
Source :
Journal of the American College of Cardiology [J Am Coll Cardiol] 2019 Mar 12; Vol. 73 (9), pp. 1078-1088.
Publication Year :
2019

Abstract

For decades, numerous observations have shown an intimate relationship between von Willebrand factor (VWF) multimer profile and heart valve diseases (HVD). The current knowledge of the unique biophysical properties of VWF helps us to understand the longstanding observations concerning the bleeding complications in patients with severe HVD. Not only does the analysis of the VWF multimer profile provide an excellent evaluation of HVD severity, it is also a strong predictor of clinical events. Also of importance, VWF responds within minutes to any significant change in hemodynamic valve status, making it an accurate marker of the quality of surgical and transcatheter therapeutic interventions. The authors provide in this review a practical, comprehensive, and evidence-based framework of the concept of VWF as a biomarker in HVD, advocating for its implementation into the clinical decision-making process besides usual clinical and imaging evaluation. They also delineate critical knowledge gaps and research priorities to definitely validate this concept.<br /> (Copyright © 2019 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.)

Details

Language :
English
ISSN :
1558-3597
Volume :
73
Issue :
9
Database :
MEDLINE
Journal :
Journal of the American College of Cardiology
Publication Type :
Academic Journal
Accession number :
30846101
Full Text :
https://doi.org/10.1016/j.jacc.2018.12.045