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Role and Impact of Chronic Cough in Individuals with Asthma From the General Population.
- Source :
-
The journal of allergy and clinical immunology. In practice [J Allergy Clin Immunol Pract] 2019 Jul - Aug; Vol. 7 (6), pp. 1783-1792.e8. Date of Electronic Publication: 2019 Mar 02. - Publication Year :
- 2019
-
Abstract
- Background: Cough is a well-recognized symptom in asthma, but the role and impact of chronic cough in individuals with asthma has not been described in the general population.<br />Objective: We hypothesized that among individuals with asthma, those with chronic cough versus those without have a more severe disease phenotype.<br />Methods: We identified individuals with asthma and chronic cough among 14,740 adults from the Copenhagen General Population Study, and investigated respiratory symptoms, health care utilizations, lung function, and biomarkers in blood.<br />Results: A total of 855 (6%) individuals suffered from asthma, and 70 (8%) had chronic cough. Individuals with asthma and chronic cough had a Leicester Cough Questionnaire median total score of 16.8 (25th and 75th percentiles, 14.8-18.9), corresponding to 5.4 (4.6-6.0) for the physical domain, 5.7 (4.6-6.4) for the psychological domain, and 6.0 (5.3-6.8) for the social domain. Among individuals with asthma, those with chronic cough versus those without reported more often wheezing (70% vs 54%), dyspnea (74% vs 49%), night-time dyspnea (27% vs 11%), sputum production (59% vs 14%), chest pain/tightness (14% vs 4%), acute bronchitis/pneumonia episodes, and general practitioner visits. Furthermore, these individuals had more often FEV <subscript>1</subscript> predicted value of less than 60% (14% vs 7%) and higher levels of neutrophils, leukocytes, and fibrinogen in blood, but there were no differences with regard to levels of high-sensitive C-reactive protein, eosinophils, and IgE in blood.<br />Conclusions: Chronic cough in individuals with asthma is associated with a more severe disease phenotype in terms of worse respiratory symptoms, greater health care utilizations, lower lung function, and higher levels of systemic inflammatory biomarkers in blood.<br /> (Copyright © 2019 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Aged
Asthma blood
Asthma physiopathology
Biomarkers blood
C-Reactive Protein analysis
Chronic Disease
Cough blood
Cough physiopathology
Denmark epidemiology
Female
Hospitalization statistics & numerical data
Humans
Leukocyte Count
Male
Middle Aged
Patient Acceptance of Health Care
Phenotype
Severity of Illness Index
Spirometry
Asthma epidemiology
Cough epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 2213-2201
- Volume :
- 7
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- The journal of allergy and clinical immunology. In practice
- Publication Type :
- Academic Journal
- Accession number :
- 30836227
- Full Text :
- https://doi.org/10.1016/j.jaip.2019.02.021