AgSCF 3 /Na 2 S 2 O 8 -Promoted Trifluoromethylthiolation/Cyclization of o-Propargyl Arylazides/ o-Alkynyl Benzylazides: Synthesis of SCF 3 -Substituted Quinolines and Isoquinolines.

Authors :: Qiu YF
Niu YJ
Wei X
Cao BQ
Wang XC
Quan ZJ
Source :: The Journal of organic chemistry [J Org Chem] 2019 Apr 05; Vol. 84 (7), pp. 4165-4178. Date of Electronic Publication: 2019 Mar 13.
Publication Year :: 2019
Abstract: A AgSCF <subscript>3</subscript> /Na <subscript>2</subscript> S <subscript>2</subscript> O <subscript>8</subscript> -promoted trifluoromethylthiolation/cascade cyclization of o-propargyl arylazides (or o-alkynyl benzylazides) triggered by a carbon-carbon triple bond is reported. This strategy provides the synthesis of valuable SCF <subscript>3</subscript> -substituted quinoline and isoquinoline systems via the construction of one C(sp <superscript>2</superscript> )-SCF <subscript>3</subscript> bond and one C-N bond within one process.

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