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Improvement of the therapeutic treatment of inflammatory bowel diseases following rectal administration of mesalazine-loaded chitosan microparticles vs Asamax ® .
- Source :
-
Carbohydrate polymers [Carbohydr Polym] 2019 May 15; Vol. 212, pp. 430-438. Date of Electronic Publication: 2019 Feb 17. - Publication Year :
- 2019
-
Abstract
- The development of innovative strategies for the efficacious treatment of inflammatory bowel diseases (IBD) still remains a goal for pharmaceutical research. Targeting the lower section of the intestine is the main aim of therapy because it is the compartment primarily affected by IBDs. Mesalazine was microencapsulated in chitosan particles in order to modulate its unfavorable pharmacokinetic profile exploiting the bioadhesive feature of the polysaccharide and increase the anti-inflammatory effect of the drug following its rectal administration in an in vivo model of induced IBD. The chitosan microparticles (1-4 μm mean size) allowed efficient retention of the mesalazine and a prolonged drug release lasting up to 48 h. In vitro and in vivo experiments confirmed the significant mucoadhesion feature of the formulation by means of mucin assay and CLSM experiments and demonstrated its therapeutic efficacy at a drug concentration 2-fold lower than the commercial formulation Asamax <superscript>®</superscript> (13 mg/kg vs 26 mg/kg).<br /> (Copyright © 2019 Elsevier Ltd. All rights reserved.)
- Subjects :
- Administration, Rectal
Animals
Anti-Inflammatory Agents, Non-Steroidal chemistry
Caco-2 Cells
Cell Survival drug effects
Cell Survival physiology
Chitosan chemistry
Colitis chemically induced
Colitis drug therapy
Colitis metabolism
Dextran Sulfate toxicity
Humans
Inflammatory Bowel Diseases chemically induced
Inflammatory Bowel Diseases metabolism
Mesalamine chemistry
Mice
Random Allocation
Treatment Outcome
Anti-Inflammatory Agents, Non-Steroidal administration & dosage
Chitosan administration & dosage
Inflammatory Bowel Diseases drug therapy
Mesalamine administration & dosage
Microspheres
Subjects
Details
- Language :
- English
- ISSN :
- 1879-1344
- Volume :
- 212
- Database :
- MEDLINE
- Journal :
- Carbohydrate polymers
- Publication Type :
- Academic Journal
- Accession number :
- 30832877
- Full Text :
- https://doi.org/10.1016/j.carbpol.2019.02.049