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Proliferator-Activated Receptor-Gamma Coactivator-1α Haploinsufficiency Promotes Pain Chronification After Burn Injury.
- Source :
-
Anesthesia and analgesia [Anesth Analg] 2020 Jan; Vol. 130 (1), pp. 240-247. - Publication Year :
- 2020
-
Abstract
- Background: Tissue injuries such as surgery and trauma are usually accompanied by simultaneous development of acute pain, which typically resolves along with tissue healing. However, in many cases, acute pain does not resolve despite proper tissue repair; rather, it transitions to chronic pain. In this study, we examined whether proliferator-activated receptor-gamma coactivator-1α (PGC-1α), a master regulator of mitochondria biogenesis, is implicated in pain chronification after burn injury in mice.<br />Methods: We used PGC-1α and littermates PGC-1α mice of both sex. Burn injury was induced on these mice. Hindpaw mechanical withdrawal thresholds and thermal withdrawal latency were examined.<br />Results: Hindpaw mechanical withdrawal thresholds and thermal withdrawal latencies were comparable at baseline between PGC-1α and PGC-1α mice. After burn injury, both PGC-1α and PGC-1α mice exhibited an initial dramatic decrease of withdrawal parameters at days 3 and 5 after injury. While PGC-1α mice fully recovered their withdrawal parameters to preinjury levels by days 11-14, PGC-1α mice failed to recover those parameters during the same time frame, regardless of sex. Moreover, we found that PGC-1α mice resolved tissue inflammation in a similar fashion to PGC-1α mice using a chemiluminescence-based reactive oxygen species imaging technique.<br />Conclusions: Taken together, our data suggest that PGC-1α haploinsufficiency promotes pain chronification after burn injury.
- Subjects :
- Acute Pain genetics
Acute Pain physiopathology
Acute Pain psychology
Adenosine Triphosphate metabolism
Animals
Brain physiopathology
Burns genetics
Burns physiopathology
Burns psychology
Chronic Pain genetics
Chronic Pain physiopathology
Chronic Pain psychology
Disease Models, Animal
Disease Progression
Female
Haploinsufficiency
Male
Mice, Inbred C57BL
Mice, Knockout
Mitochondria metabolism
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha genetics
Reaction Time
Wound Healing
Acute Pain metabolism
Behavior, Animal
Brain metabolism
Burns metabolism
Chronic Pain metabolism
Pain Threshold
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha deficiency
Subjects
Details
- Language :
- English
- ISSN :
- 1526-7598
- Volume :
- 130
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Anesthesia and analgesia
- Publication Type :
- Academic Journal
- Accession number :
- 30829673
- Full Text :
- https://doi.org/10.1213/ANE.0000000000004086